|
Congenital central hypoventilation
|
0.620 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Risk Factor Genes in Patients with Dystonia: A Comprehensive Review.
|
30643666 |
2018 |
|
Congenital central hypoventilation
|
0.620 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Role of BDNF in central motor structures and motor diseases.
|
23649659 |
2013 |
|
Congenital central hypoventilation
|
0.620 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations.
|
15657604 |
2005 |
|
Congenital central hypoventilation
|
0.620 |
GeneticVariation
|
disease |
BEFREE |
Other mutations, generally inherited from one of the parents, in the coding regions of genes involved in the endothelin and RET signaling pathways and in the brain-derived-neurotrophic factor (BDNF) gene have been found in a few CCHS patients.
|
14739359 |
2004 |
|
Congenital central hypoventilation
|
0.620 |
GeneticVariation
|
disease |
ORPHANET |
The objective of this study was to determine the frequency of BDNF mutations among 19 children with CCHS (five with HSCR) compared to 40 unaffected unrelated controls.
|
11840487 |
2002 |
|
Congenital central hypoventilation
|
0.620 |
GeneticVariation
|
disease |
UNIPROT |
The objective of this study was to determine the frequency of BDNF mutations among 19 children with CCHS (five with HSCR) compared to 40 unaffected unrelated controls.
|
11840487 |
2002 |
|
Congenital central hypoventilation
|
0.620 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to determine the frequency of BDNF mutations among 19 children with CCHS (five with HSCR) compared to 40 unaffected unrelated controls.
|
11840487 |
2002 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results provide the first evidence that the miR-134-mediated post-transcriptional regulation of CREB-1 and BDNF is an important molecular mechanism underlying the plasticity deficit in AD; thus demonstrating the critical role of miR-134-5p as a potential therapeutic target for restoring plasticity in AD condition.
|
31625272 |
2020 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggested that AD or MCI is accompanied by reduction of peripheral BDNF, but the levels of circulating BDNF may not be suitable as a diagnostic marker for AD and MCI.
|
31518516 |
2020 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Injection of L-T4 (10 μg/kg) alleviated memory deficits and also improved factors of oxidative stress and BDNF level in the STZ-induced AD rats.
|
29927658 |
2020 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), contributing to neuronal atrophy in the prefrontal cortex (PFC) and hippocampus, and reduced hippocampal adult neurogenesis.
|
31830487 |
2020 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The proposed model is testable and implies that low levels and low variability in serum BDNF are associated with poor response to anti-depressive medications, electroconvulsive therapy, and REM sleep deprivation, in patients with depression.
|
31782101 |
2020 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In PSD patients, the presence of stroke may contribute to the development of depression, including affecting the expression of BDNF.
|
31385340 |
2020 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Major depressive disorder (MDD) is associated with stress-induced immune dysregulation and reduced brain-derived neurotrophic factor (BDNF) levels in sensitive brain regions associated with depression.
|
31532659 |
2020 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, elevated miR-133b and inhibited CTGF could restrain apoptosis of hippocampal neurons, repress inflammatory reaction, and increase the expression of GFAP, BDNF and neurotransmitters in hippocampal tissues of depression rats, resulting in a protective impact on neural injury in depression rats.
|
31830619 |
2020 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Importantly, early life stressors that affect BDNF production are known to predispose individuals towards the later development of depression or anxiety disorders.
|
31568835 |
2020 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, little is known about the relationship between memory performance and depression severity, about the course of memory performance during antidepressant treatment as well as about the relationship between memory performance and brain-derived neurotrophic factor (BDNF).
|
30929060 |
2020 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU).
|
31319037 |
2020 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Reduced levels of brain derived neurotrophic factor (BDNF), through its role in neurogenesis and neuroplasticity, may be involved in the evolution and maintenance of depression.
|
31364951 |
2020 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, little is known about the relationship between memory performance and depression severity, about the course of memory performance during antidepressant treatment as well as about the relationship between memory performance and brain-derived neurotrophic factor (BDNF).
|
30929060 |
2020 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Major depressive disorder (MDD) is associated with stress-induced immune dysregulation and reduced brain-derived neurotrophic factor (BDNF) levels in sensitive brain regions associated with depression.
|
31532659 |
2020 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In PSD patients, the presence of stroke may contribute to the development of depression, including affecting the expression of BDNF.
|
31385340 |
2020 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additionally, elevated miR-133b and inhibited CTGF could restrain apoptosis of hippocampal neurons, repress inflammatory reaction, and increase the expression of GFAP, BDNF and neurotransmitters in hippocampal tissues of depression rats, resulting in a protective impact on neural injury in depression rats.
|
31830619 |
2020 |