Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sortilin involves in lipid metabolism, promotes the development of atherosclerosis, and possibly becomes a potential therapeutic target for atherosclerosis treatment.
|
27312323 |
2016 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sortilin is involved in the development of atherosclerosis, but the specific mechanism is unclear.
|
29196163 |
2018 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages, leading to foam cell formation and AS development.
|
30950489 |
2019 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chronic inflammation is a hallmark of atherosclerosis and the absence of regulatory T (Treg) cells is associated with reduced protein expression of sortilin-1 in the liver.
|
28742217 |
2017 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, sortilin also seems to be involved in the development of atherosclerosis, by mechanisms not directly involving LDL-cholesterol, but possibly resulting from the attenuated secretion of proinflammatory cytokines, such as IL6 and TNFα, which accompanies lack of sortilin in immune cells.
|
25702058 |
2015 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the last two decades, deregulation of sortilin has been demonstrated to be involved in many human pathophysiologies, including neurodegenerative disorders (Alzheimer and Parkinson diseases), type 2 diabetes and obesity, cancer, and cardiovascular pathologies such as atherosclerosis.
|
30666202 |
2018 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interrogation of the Atherosclerosis-Associated <i>SORT1</i> (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice.
|
29097363 |
2018 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This article provides a comprehensive review of sortilin's contributions to cardiovascular and metabolic diseases but focuses particularly on atherosclerosis.
|
29191923 |
2018 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data demonstrate that sortilin influences cytokine secretion and that targeting sortilin in immune cells attenuates inflammation and reduces atherosclerosis.
|
25401472 |
2014 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Understanding the mechanism by which sortilin affects LDL cholesterol will increase our understanding of the regulation of lipoprotein metabolism and hepatic lipoprotein export and may also allow us to harness the power of the 1p13 SORT1 locus for the treatment of atherosclerotic cardiovascular disease.
|
25101658 |
2014 |
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the relationship between rs599839 and rs646776 single nucleotide polymorphisms (SNPs) present in the CELSR2-PSRC1-SORT1 gene cluster, candidate gene expression, and their association with CAD and circulating lipid levels in a representative cohort of Asian Indians selected from the Indian Atherosclerosis Research Study.
|
24674750 |
2014 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We showed that sortilin is significantly and independently associated with the presence of lower limb PAD in a statin-free diabetic population and it may be a promising marker for clinically significant atherosclerosis of the lower limbs.
|
30634965 |
2019 |