Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages, leading to foam cell formation and AS development.
|
30950489 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We showed that sortilin is significantly and independently associated with the presence of lower limb PAD in a statin-free diabetic population and it may be a promising marker for clinically significant atherosclerosis of the lower limbs.
|
30634965 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sortilin is involved in the development of atherosclerosis, but the specific mechanism is unclear.
|
29196163 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the last two decades, deregulation of sortilin has been demonstrated to be involved in many human pathophysiologies, including neurodegenerative disorders (Alzheimer and Parkinson diseases), type 2 diabetes and obesity, cancer, and cardiovascular pathologies such as atherosclerosis.
|
30666202 |
2018 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interrogation of the Atherosclerosis-Associated <i>SORT1</i> (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice.
|
29097363 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This article provides a comprehensive review of sortilin's contributions to cardiovascular and metabolic diseases but focuses particularly on atherosclerosis.
|
29191923 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chronic inflammation is a hallmark of atherosclerosis and the absence of regulatory T (Treg) cells is associated with reduced protein expression of sortilin-1 in the liver.
|
28742217 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sortilin involves in lipid metabolism, promotes the development of atherosclerosis, and possibly becomes a potential therapeutic target for atherosclerosis treatment.
|
27312323 |
2016 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, sortilin also seems to be involved in the development of atherosclerosis, by mechanisms not directly involving LDL-cholesterol, but possibly resulting from the attenuated secretion of proinflammatory cytokines, such as IL6 and TNFα, which accompanies lack of sortilin in immune cells.
|
25702058 |
2015 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the relationship between rs599839 and rs646776 single nucleotide polymorphisms (SNPs) present in the CELSR2-PSRC1-SORT1 gene cluster, candidate gene expression, and their association with CAD and circulating lipid levels in a representative cohort of Asian Indians selected from the Indian Atherosclerosis Research Study.
|
24674750 |
2014 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data demonstrate that sortilin influences cytokine secretion and that targeting sortilin in immune cells attenuates inflammation and reduces atherosclerosis.
|
25401472 |
2014 |