S100B, S100 calcium binding protein B, 6285

N. diseases: 599; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0272199
Disease: Familial Hemophagocytic Lymphocytosis
Familial Hemophagocytic Lymphocytosis 		0.010 Biomarker phenotype BEFREE These studies demonstrated that the FEL histiocytes lack S-100 protein, T6, and Birbeck granules, which are found in Langerhans and interdigitating dendritic cells. 3080365 1986
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.400 Biomarker disease BEFREE Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome. 2964086 1988
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome 		0.100 Biomarker disease BEFREE Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome. 2964086 1988
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.020 Biomarker disease BEFREE S-100 beta +T cell leukemia/lymphoma is a new type of s/c T lymphocytic leukemia/lymphoma with aggressive features. 2896028 1988
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Improved detection of aneuploidy in malignant melanoma using multiparameter flow cytometry for S100 protein and DNA content. 2768839 1989
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.100 GeneticVariation disease BEFREE A stretch of approximately 30 bases in the nef gene of HIV-1BR was found duplicated when compared with the other sequenced HIV-1 genomes. 2789516 1989
CUI: C0017638
Disease: Glioma
Glioma 		0.070 Biomarker disease BEFREE A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. 2589023 1989
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.040 Biomarker disease BEFREE A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. 2589023 1989
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.040 Biomarker disease BEFREE A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. 2589023 1989
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 Biomarker disease BEFREE A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. 2589023 1989
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.030 Biomarker disease BEFREE A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. 2589023 1989
CUI: C0343751
Disease: Asymptomatic human immunodeficiency virus infection
Asymptomatic human immunodeficiency virus infection 		0.010 GeneticVariation disease BEFREE Antibody responses against the nef gene product of HIV-1 were determined in sequential sera from a longitudinally studied cohort of 194 initially asymptomatic HIV-1-seropositive individuals and 72 individuals who seroconverted for antibodies to HIV-1 structural proteins (gag/env). 2500956 1989
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.400 AlteredExpression disease BEFREE These results indicate that gene-dosage effect of S-100 beta levels are expressed in DS patients. 2150320 1990
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.400 Biomarker disease BEFREE This raises the possibility that abnormalities in S100 protein gene dosage at a critical period during development may be responsible for some of the neurologic abnormalities associated with DS. 2146955 1990
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Flow cytometric analysis of individual cells of two melanoma cell lines and the rat glioma cell line C6 indicated that G0/G1 cells were heterogeneous with respect to S100 protein expression, while almost all the cells in S + G2 + M expressed S100 protein. 2298261 1990
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Immunostaining revealed that the tumors were positive for S-100 protein and vimentin and negative for glial fibrillary acidic protein, actin, and keratin. 2305928 1990
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.100 Biomarker disease BEFREE Antibodies to nef protein, a regulator of HIV-1 replication, may be an early indicator of HIV infection. 2202798 1990
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.100 Biomarker disease BEFREE In contrast, the HIV-2 nef- mutant infected human macrophages as efficiently as the parental virus, whereas viruses lacking the vpr gene either alone or in conjunction with the lack of the nef gene did not replicate in macrophages. 2236020 1990
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.100 Biomarker disease BEFREE Constitutive expression of human immunodeficiency virus (HIV) nef protein in human astrocytes does not influence basal or induced HIV long terminal repeat activity. 2186177 1990
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome 		0.100 Biomarker disease BEFREE This raises the possibility that abnormalities in S100 protein gene dosage at a critical period during development may be responsible for some of the neurologic abnormalities associated with DS. 2146955 1990
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome 		0.100 AlteredExpression disease BEFREE These results indicate that gene-dosage effect of S-100 beta levels are expressed in DS patients. 2150320 1990
CUI: C0017638
Disease: Glioma
Glioma 		0.070 AlteredExpression disease BEFREE Flow cytometric analysis of individual cells of two melanoma cell lines and the rat glioma cell line C6 indicated that G0/G1 cells were heterogeneous with respect to S100 protein expression, while almost all the cells in S + G2 + M expressed S100 protein. 2298261 1990
CUI: C1864445
Disease: Histiocytosis with joint contractures and sensorineural deafness
Histiocytosis with joint contractures and sensorineural deafness 		0.030 AlteredExpression disease BEFREE SHML cells expressed the following: (1) S-100 protein, (2) "pan-macrophage" antigens such as EBM11, HAM 56, and Leu-M3, (3) antigens functionally associated with phagocytosis (Fc receptor for IgG, complement receptor 3), and lysosomal activity (lysozyme, alpha 1-antichymotrypsin, and alpha 1-antitrypsyn), (4) antigens associated with early inflammation (Mac-387, 27E10), (5) antigens commonly found on monocytes, but not tissue macrophages (OKM5, Leu-M1), and (6) "activation" antigens (Ki-1 and receptors for transferrin and interleukin 2). 2180014 1990
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.020 AlteredExpression disease BEFREE Since human immunodeficiency virus (HIV) nef has been suggested to exert regulatory effects on HIV long terminal repeat (LTR) activity, we transiently transfected HIV LTR chloramphenicol acetyltransferase or luciferase expression vectors into a human astrocytoma clone (U-373nef) that constitutively expresses the HIV nef gene. 2186177 1990
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 AlteredExpression disease BEFREE Since human immunodeficiency virus (HIV) nef has been suggested to exert regulatory effects on HIV long terminal repeat (LTR) activity, we transiently transfected HIV LTR chloramphenicol acetyltransferase or luciferase expression vectors into a human astrocytoma clone (U-373nef) that constitutively expresses the HIV nef gene. 2186177 1990