AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the SAA1 -13T allele, rather than SAA1 exon 3 haplotypes, is primarily associated with AA amyloidosis risk.
|
11407685 |
2001 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with FMF or a rheumatic disease and the SAA1 α/α genotype had a relative risk of 4.86 and 2.53, respectively, for developing an AA amyloidosis.
|
25376380 |
2015 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We treated 14 RA patients who had serum amyloid A protein (SAA) 1.3 allele, with biopsy-confirmed AA amyloidosis with etanercept and investigated the efficacy of etanercept treatment, focusing on renal function retrospectively.
|
20440529 |
2010 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SAA1 gene polymorphisms and the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis.
|
17039310 |
2006 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results of the analysis of real data indicated that a significant association between haplotypes in the SAA1 gene and AA-amyloidosis phenotype was observed in patients with rheumatoid arthritis, thereby suggesting the validity of the application of PENHAPLO for case-control data.
|
16980401 |
2006 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, the SAA1 polymorphism was confirmed as a susceptibility factor for AA amyloidosis irrespective of the type of the disease.
|
29364741 |
2018 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous reports have indicated that the -13T/C single nucleotide polymorphism (SNP) at the 5'-flanking region of SAA1 appears to be a better marker of AA-amyloidosis than the exon-3 based haplotype, i.e., SAA1.1 or SAA1.3, in both Japanese and American Caucasian populations.
|
16076608 |
2005 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of the four human SAA genotypes, SAA1 is most commonly associated with AA amyloidosis.
|
24440699 |
2014 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The contributions of ageing, inflammatory activity, SAA1 exon 3 polymorphism as well as gender to the pathogenesis of AA amyloidosis in 144 cases were also studied by multiple regression analysis.
|
21627560 |
2011 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis.
|
17968686 |
2007 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we report that there was a significant difference in the observed numbers of SAA1 alleles between rheumatoid arthritis patients with AA-amyloidosis and the control population (chi 2(2) = 11.59, p = 0.003) with a higher frequency of gamma-allele in the AA-amyloid group (0.70 vs. 0.37).
|
7655463 |
1995 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Another report revealed a strong association between SAA1 -13T/C and secondary amyloidosis in the rheumatoid arthritis patient group.
|
16874691 |
2006 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that -13T is a genetic background for AA amyloidosis in both Japanese and Caucasians and the difference in prevalence of AA amyloidosis in the two ethnic groups may be due, at least in part, to a difference in the frequency of the -13T SAA1 allele.
|
12762135 |
2003 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, the mean C-reactive protein (CRP) level during 2 years prior to the diagnosis of AA-amyloidosis was significantly higher in the patients with larger numbers of the gamma allele at the SAA1 locus (Spearman's correlation coefficient: 0.34, P<0.05).
|
10543406 |
1999 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
His mother was also a carrier of the SAA1.3 allele, which is not only a univariate predictor of survival but also a risk factor for the association of AA amyloidosis with rheumatoid arthritis in Japanese patients, and the SAA1-13T allele in the 13T/C polymorphism on the 5'-flanking region of the SAA1 gene.
|
24593212 |
2014 |
AA amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Development of AA amyloidosis is rare in FMF patients without amyloidogenic single nucleotide polymorphisms (SNPs) (713T allele) of the SAA1 gene.
|
19339884 |
2009 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In systemic amyloidosis, SAA was more sensitive than CRP as an indicator of the acute-phase response, particularly in secondary amyloidosis.
|
4085162 |
1986 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that there is probably differential amyloidogenicity amongst the different SAA1 isoforms and indicate that homozygosity for SAA1 alpha and SAA1 gamma in the different populations is a significant risk factor for development of AA amyloidosis.
|
10036584 |
1998 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum amyloid A1 (SAA1) is an apolipoprotein that binds to the high-density lipoprotein (HDL) fraction of the serum and constitutes the fibril precursor protein in systemic AA amyloidosis.
|
28637682 |
2017 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This significant result indicates that a normal f-SAA will indicate a minimal or even absent risk of succumbing to AA amyloidosis.
|
19657764 |
2009 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
AA amyloidosis invariably has been associated with fibrillar deposits of the acute phase high-density lipoprotein serum amyloid A isotypes SAA1 and SAA2.
|
20536400 |
2009 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-tumor necrosis factor agents (anti-TNFs) were shown to decrease the production of serum amyloid A protein.We aimed to evaluate the long-term efficacy and safety of anti-TNFs in secondary (AA) amyloidosis patients treated in a single center.Thirty-seven patients with AA amyloidosis were started an anti-TNF for AA amyloidosis between March 2001 and June 2008 and followed until May 2016 unless deceased.
|
28834898 |
2017 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cell-to-cell transfer of SAA1 protein in a cell culture model of systemic AA amyloidosis.
|
28361953 |
2017 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum amyloid A protein (SAA) is a precursor for a major component of amyloid fibrils, which, upon deposition, cause secondary amyloidosis in diseases such as rheumatoid arthritis.
|
3456645 |
1986 |
AA amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronically elevated A-SAA concentrations are a prerequisite for the pathogenesis of secondary amyloidosis, a progressive and fatal disease characterized by the deposition in major organs of insoluble plaques composed principally of proteolytically cleaved A-SAA, and may also contribute to physiological processes that lead to atherosclerosis.
|
9729453 |
1998 |