Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype BEFREE The sodium channel 1.7 (Nav1.7), which is encoded by SCN9A gene, is involved in neuropathic pain. 30425258 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype BEFREE Based on bioinformatics analysis using TargetScan software, we determined that miR-30b directly targets SCN9A To investigate the roles of Nav1.7 and miR-30b in neuropathic pain, we examined changes in the expression of Nav1.7 in the dorsal root ganglion by miR-30b over-expression or knockdown in rats with spared nerve injury. 27765894 2016
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 GeneticVariation phenotype BEFREE The exonic regions of SCN9A were sequenced in a subset of 244 patients with neuropathic pain, and the variants discovered were compared with POPRES control (stage 1). 25585270 2015
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 GeneticVariation phenotype BEFREE To investigate mutations in the SCN9A gene in patients with chronic non-paroxysmal neuropathic pain. 21094958 2011
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype CTD_human A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia. 19557861 2009
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.350 Biomarker phenotype BEFREE Recent advances in the genetics of pain and pain disorders include the discovery of the role of the sodium ion channel SCN9A in neuropathic pain as well as in inability to experience pain, and of GTP cyclohydrolase (GCH1) in setting the sensitivity to pain in normal individuals and modulating liability to chronic pain. 17508172 2007