|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
GWASDB |
Through a genome-wide association study of 312 individuals with Brugada syndrome and 1,115 controls, we detected 2 significant association signals at the SCN10A locus (rs10428132) and near the HEY2 gene (rs9388451).
|
23872634 |
2013 |
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to identify the frequency of SCN10A mutations in Japanese patients with BrS and to compare the phenotypical differences between patients with BrS and those who have other BrS-causative genes.
|
25842276 |
2016 |
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
GWASCAT |
Through a genome-wide association study of 312 individuals with Brugada syndrome and 1,115 controls, we detected 2 significant association signals at the SCN10A locus (rs10428132) and near the HEY2 gene (rs9388451).
|
23872634 |
2013 |
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, a genome-wide association study revealed that a common variant in SCN10A or HEY2 in addition to SCN5A is associated with BrS, thus, BrS may not be a monogenic Mendelian disease but probably an oligogenic disease.
|
30910390 |
2019 |
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF.
|
24667784 |
2014 |
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The SCN10A SNP V1073 was, however, associated strongly with BrS [66.9 vs. 40.1% (UK10K) OR (95% CI) = 3.02 (2.35-3.87), P = 8.07 × 10-19].
|
25691538 |
2015 |
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Multiple genome-wide association studies (GWAS) and targeted gene sequencing have identified common variants in SCN10A in cases of PR and QRS duration abnormalities, atrial fibrillation and Brugada syndrome.
|
31195250 |
2019 |
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Variants in SCN10A, which encodes a voltage-gated sodium channel, are associated with alterations of cardiac conduction parameters and the cardiac rhythm disorder Brugada syndrome; however, it is unclear how SCN10A variants promote dysfunctional cardiac conduction.
|
24642470 |
2014 |
|
Brugada Syndrome (disorder)
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
|
23872634 |
2013 |
|
EPISODIC PAIN SYNDROME, FAMILIAL, 2
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Gain-of-function Nav1.8 mutations in painful neuropathy.
|
23115331 |
2012 |
|
Atrial Fibrillation
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
SCN10A variants were also associated with subsequent development of atrial fibrillation and arrhythmia in the original 5272 "heart-healthy" study population.
|
23463857 |
2013 |
|
Atrial Fibrillation
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
In this meta-analysis, both rs10428132 at SCN10A (OR=0.73, P=5.7 × 10(-6)) and rs11708996 at SCN5A (OR=0.80, P=0.02) showed a statistically significant decreased risk of AF.
|
24667784 |
2014 |
|
Atrial Fibrillation
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that genetic variation in SCN10A may play an important role in predicting AF recurrence after catheter ablation in the Chinese Han population.
|
28281580 |
2017 |
|
Atrial Fibrillation
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
In summary, our study suggests the possible involvement of the SCN10A variant in AF development in Chinese Han populations.
|
27725708 |
2016 |
|
Atrial Fibrillation
|
0.480 |
GeneticVariation
|
disease |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Atrial Fibrillation
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
In addition, this single nucleotide polymorphism trended towards an association with heart rate response during AF indicating the importance of this common SCN10A polymorphism as a marker of atrioventricular conduction.
|
24072447 |
2014 |
|
Atrial Fibrillation
|
0.480 |
GeneticVariation
|
disease |
GWASCAT |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
Atrial Fibrillation
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Rare SCN10A variants encoding Nav1.8 were identified in 6.6% of patients with early onset AF.
|
25053638 |
2014 |
|
Small Fiber Neuropathy
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous mutations in TRPA1, which encodes the transient receptor potential cation channel, can cause familial episodic pain syndromes, and variants of genes coding for the voltage-gated sodium channels Nav1.8 (SCN10A) and Nav1.9 (SCN11A) lead to small-fibre neuropathy and congenital insensitivity to pain, respectively.
|
24813307 |
2014 |
|
Small Fiber Neuropathy
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies expanded the panel on genes involved in SFN because of the discovery of new mutations in SCN10A and SCN11A, besides the first found in SCN9A, and identification of mutations in COL6A5 in patients with itching.
|
28665811 |
2017 |
|
Small Fiber Neuropathy
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Generation of two induced pluripotent stem cell lines from skin fibroblasts of sisters carrying a c.1094C>A variation in the SCN10A gene potentially associated with small fiber neuropathy.
|
30731422 |
2019 |
|
Heart Block
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In addition, the A allele remained significant after adjusting for other covariates in a multivariate model (odds ratio = 6.30 [95% confidence interval: 2.24 to 19.09], P = 0.0005).The rs6795970 in the SCN10A gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in HCM patients.
|
26104176 |
2015 |
|
Heart Block
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
We have shown that the gene SCN10A encoding the sodium channel Na(v)1.8 is a susceptibility factor for heart block and serious ventricular arrhythmia.
|
21646736 |
2011 |
|
Neuralgia
|
0.320 |
GeneticVariation
|
phenotype |
BEFREE |
We report here a patient with painful diabetic peripheral neuropathy and negative genetic screening for mutations in SCN9A, SCN10A, and SCN11A-genes encoding sodium channel α-subunit that have been previously linked to the development of neuropathic pain.
|
31041876 |
2020 |