Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011175
Disease: Dehydration
Dehydration
0.140 Biomarker phenotype BEFREE The epithelial sodium channel ENaC consists of three subunits encoded by Scnn1a, Scnn1b, and Scnn1g and increased sodium absorption through this channel is hypothesized to lead to mucus dehydration and accumulation in cystic fibrosis (CF) patients. 30100257 2019
CUI: C0011175
Disease: Dehydration
Dehydration
0.140 AlteredExpression phenotype BEFREE Cumulatively, these results indicate that overexpression of βENaC is rate limiting for generation of pathological airway surface dehydration. 29074490 2018
CUI: C0011175
Disease: Dehydration
Dehydration
0.140 Biomarker phenotype BEFREE To address these questions, Scnn1b-Tg mice, which exhibit airway mucus dehydration/adhesion, were compared and crossed with Muc5b- and Muc5ac-deficient mice. 27435107 2017
CUI: C0011175
Disease: Dehydration
Dehydration
0.140 Biomarker phenotype BEFREE Scnn1b-Tg mice, which exhibit chronic airway surface dehydration from birth, can be used as a model to study the pathogenesis of muco-obstructive lung disease across developmental stages. 25204199 2014
CUI: C0011175
Disease: Dehydration
Dehydration
0.140 Biomarker phenotype HPO