|
Malignant neoplasm of breast
|
0.310 |
Biomarker
|
disease |
BEFREE |
The triple negative human breast cancer cell lines MDA-MB231 and its sub-progenies SCP2 and SCP25, SUM159PT, SUM149PT, SUM229PE and SUM1315MO2 were treated with 5 ng/ml TGFβ and the protein expression levels were measured by Western blot.
|
22995475 |
2012 |
|
Dystonia
|
0.310 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations in the gene encoding peroxisomal sterol carrier protein X (SCPx) cause leukencephalopathy with dystonia and motor neuropathy.
|
16685654 |
2006 |
|
Fatty Liver
|
0.030 |
Biomarker
|
disease |
BEFREE |
Studies in vitro have suggested that both sterol carrier protein-2/sterol carrier protein-x (<i>Scp-2/Scp-x</i>) and liver fatty acid binding protein [<i>Fabp1</i> (L-FABP)] gene products facilitate hepatic uptake and metabolism of lipotoxic dietary phytol.
|
28411199 |
2017 |
|
Fatty Liver
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Primarily in female mice, hepatic cholesterol accumulation induced by SCP-2 overexpression was associated with increased levels of LDL-receptor, HDL-receptor scavenger receptor-B1 (SR-B1) (as well as PDZK1 and/or membrane-associated protein 17 kDa), SCP-2, liver fatty acid binding protein (L-FABP), and 3alpha-hydroxysteroid dehydrogenase, without alteration of other proteins involved in cholesterol uptake (caveolin), esterification (ACAT2), efflux (ATP binding cassette A-1 receptor, ABCG5/8, and apolipoprotein A1), or oxidation/transport of bile salts (cholesterol 7alpha-hydroxylase, sterol 27alpha-hydroxylase, Na(+)/taurocholate cotransporter, Oatp1a1, and Oatp1a4).
|
19289417 |
2009 |
|
Fatty Liver
|
0.030 |
Biomarker
|
disease |
BEFREE |
In vitro studies suggest that liver fatty acid binding protein (L-FABP) and sterol carrier protein-2/sterol carrier protein-x (SCP2/SCPx) gene products facilitate uptake and metabolism and detoxification of dietary-derived phytol in mammals.
|
27940000 |
2017 |
|
Non-alcoholic Fatty Liver Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Based on the results, the promoting effects of EPA-PC on NAFLD may be partly associated with the suppression of cholesterol synthesis via HMGR inhibition and the enhancement of fecal cholesterol excretion through increased SCP2 transcription.
|
28012135 |
2017 |
|
Non-alcoholic Fatty Liver Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although singly ablating Fabp1 or Scp2/Scpx genes may exacerbate the impact of high fat diet (HFD) on whole body phenotype and non-alcoholic fatty liver disease (NAFLD), concomitant upregulation of the non-ablated gene, preference for ad libitum fed HFD, and sex differences complicate interpretation.
|
29307784 |
2018 |
|
Cholesterol gallstones
|
0.020 |
Biomarker
|
disease |
BEFREE |
The SCP2 gene was overexpressed in patients with cholesterol gallstone, indicating that SCP2 may be one of the important causes of cholesterol gallstone.
|
15730934 |
2005 |
|
Cholesterol gallstones
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, SCP2 was expressed at higher levels in hereditary cholesterol gallstone patients than that of non-hereditary cholesterol gallstone patients.
|
21310066 |
2011 |
|
Small vessel vasculitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, immunization with rSCP2<sub>518-532</sub> accelerated the development of SVV in the rat model.
|
27863214 |
2017 |
|
Small vessel vasculitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In line with this, CD1d-restricted type II NKT cells that recognize type II collagen peptide have been demonstrated to act as anti-inflammatory cells in diverse inflammation-induction models in mice, whereas pro-inflammatory CD1d-restricted type II NKT cells reactive with sterol carrier protein 2 peptide have been demonstrated to be involved in the development of small vessel vasculitis in rats.
|
29599785 |
2018 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The sterol carrier protein SCP-x/pro-SCP-2 gene has transcriptional activity and regulates the Alzheimer disease gamma-secretase.
|
17485462 |
2007 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
SCP2/SCPx deficiency attenuated atherosclerosis in LS mice by >80% and significantly reduced plasma cholesterol and triglyceride levels.
|
29700117 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
SCP2/SCPx deficiency attenuated atherosclerosis in LS mice by >80% and significantly reduced plasma cholesterol and triglyceride levels.
|
29700117 |
2018 |
|
Connective Tissue Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Type II Natural Killer T Cells that Recognize Sterol Carrier Protein 2 Are Implicated in Vascular Inflammation in the Rat Model of Systemic Connective Tissue Diseases.
|
27863214 |
2017 |
|
Hypercholesterolemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In vivo, SCP2 overexpression and high cholesterol diet could promote tumor growth.
|
31519191 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SCP-1 and SCP-2 also increased the activities of glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD), as well as decreased the content of malondialdehyde (MDA) in the hyperglycemia mice.
|
30529353 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that the phosphatase SCP1 and its isoforms SCP2/3 dephosphorylate PML at S518, thereby blocking PML ubiquitination and degradation mediated by the prolyl isomerase Pin1 and the ubiquitin ligase KLHL20.
|
25293974 |
2014 |
|
Pituitary Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of SCP2 promoted PA cell lines proliferation in vitro.
|
31519191 |
2019 |
|
Refsum Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
A sterol-carrier protein-2 (SCP-2) knockout mouse model shares a similar clinical phenotype to Refsum's disease, but no mutations in SCP-2 have been described to-date in man.
|
11948235 |
2002 |
|
Vasculitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although further studies to clarify the mechanism and significance of this phenomenon are needed, SCP2/CD1d tetramer-binding type II NKT cells in peripheral blood should be examined in more detail to understand the pathophysiology of vasculitides in humans.
|
30253046 |
2018 |
|
Congenital pectus carinatum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we evaluated the expression characteristics of miR-15a and its relationship with the expression of acetyl-CoA acyltransferase 1 (<i>ACAA1</i>), acyl-CoA oxidase 1 (<i>ACOX1</i>) and sterol carrier protein 2 (<i>SCP2</i>) by qPCR analysis in Gushi chicken breast muscle at 6, 14, 22, and 30 weeks old, where we performed transfection tests of miR-15a mimics in intramuscular preadipocytes and verified the target gene of miR-15a in chicken fibroblasts (DF1).
|
31434294 |
2019 |
|
Adrenocortical carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mRNA concentrations of SCP2 in two out of three adrenocortical carcinomas were relatively lower than those in other types of tissue.
|
8640304 |
1996 |
|
Congenital contractural arachnodactyly
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genes MRPS18A, CST1, and SCP2 were identified as candidate genes in the module, which was associated with clinical traits including pathological stage, histological grade, and liver function and which also affected overall survival of CCA patients.
|
31177590 |
2019 |
|
Peripheral motor neuropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the gene encoding peroxisomal sterol carrier protein X (SCPx) cause leukencephalopathy with dystonia and motor neuropathy.
|
16685654 |
2006 |