CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype BEFREE These findings suggest that ganglionic CCL2/CCR2 signaling is a therapeutic target for the treatment of trigeminal inflammatory hyperalgesia. 28780056 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype BEFREE Cotreatment with intrathecal anti-CCL2 antibodies prevented the development of oxaliplatin-induced mechanical hyperresponsiveness, and transiently reversed established hyperalgesia when given 1 week after chemotherapy. 29554018 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype BEFREE These results are in agreement with previous reports concerning the involvement of CCL2-CCR2 signaling in inflammatory hyperalgesia and further indicate that enhanced TTX-sensitive channel activity may partly underlie the pronociceptive effects of CCL2. 30339176 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype BEFREE The CCL2 elevation in primary afferent fibers produces zymosan-induced hyperalgesia through microglia-mediated neuronal activation in the spinal dorsal horn. 31005664 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype BEFREE In addition, anti-MCP-1 antibodies were intrathecally injected to rats in various groups in order to investigate the association of MCP-1 with mechanical and heat hyperalgesia using the paw withdrawal threshold (PWT) and thermal withdrawal latency (TWL) tests, respectively. 28352316 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype BEFREE We found that spinal injection of the CCR2 antagonist RS504393 attenuated CCL2- and inflammation-induced hyperalgesia. 28265898 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype BEFREE Peripheral but not central activation of cyclooxygenase-2 (Cox-2) were critical for CCL2-induced hyperalgesia. 23683582 2013
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype CTD_human Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain. 17881535 2007
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype RGD Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. 18419759 2008
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype RGD Expression of monocyte chemoattractant protein-1 and its induction by tumor necrosis factor receptor 1 in sensory neurons in the ventral rhizotomy model of neuropathic pain. 21712071 2011
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.570 Biomarker phenotype RGD Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats. 22531750 2012