CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker disease BEFREE This study was thus conducted to determine plasma MCAF in patients with ESRD. 8808219 1995
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker disease RGD Our findings indicate localized expression of MCP-1 in proximal tubular cells in the remnant kidney and suggest that MCP-1 in proximal tubular cells is involved in tubulointerstitial damage in chronic kidney failure associated with glomerular hypertension. 12080327 2002
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 GeneticVariation disease BEFREE In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population. 17728497 2007
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker disease LHGDN The aim of this study was to determine if measurements of urinary epidermal growth factor (EGF) and monocyte chemotactic peptide-1 (MCP-1), at the time of renal biopsy, were a predictor of end-stage renal disease (ESRD) in a cohort of 132 patients with biopsy-proven IgAN. 17943082 2008
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Therapeutic disease RGD Sedentary CRF rats exhibited azotemia, hypertension, anemia, oxidative stress, activation of NF-kappaB and upregulations of reactive oxygen species-generating enzyme, NAD(P)H oxidase, MCP-1, cyclooxygenase-2 (COX-2), and PAI-1 in LV. 18797164 2009
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 GeneticVariation disease BEFREE There was no statistically significant difference in the distribution of MCP-1 genotypes between ESRD patients without CVD and healthy controls. 19014891 2008
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker disease CTD_human Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110 2009
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker disease CTD_human Adiponectin receptor-1 and monocyte chemoattractant protein-1 mRNA expressions were significantly higher in visceral but not in subcutaneous adipose tissue of the ESRD group. 19539174 2009
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 AlteredExpression disease BEFREE Adiponectin receptor-1 and monocyte chemoattractant protein-1 mRNA expressions were significantly higher in visceral but not in subcutaneous adipose tissue of the ESRD group. 19539174 2009
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker disease BEFREE We showed that HDL from patients with ESRD has a lower anti-inflammatory potential by reduced inhibition of monocyte chemoattractant protein-1 formation in vascular smooth muscle cells. 22328092 2012
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 GeneticVariation disease BEFREE Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model). 22817530 2012
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 GeneticVariation disease BEFREE MCP-1 -2518 GG genotype and G allele may increase the risk of progression to ESRD in T2D cases. 25154422 2015
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 GeneticVariation disease BEFREE Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy. 25280384 2014
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 GeneticVariation disease BEFREE Therefore, in this study, we aimed to investigate the effect of MCP-1 gene -2518 A>G promoter polymorphism in chronic renal failure (CRF) patients requiring long-term hemodialysis. 25655256 2015
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 Biomarker disease BEFREE Furthermore, H<sub>2</sub>S decreased the expression levels of tumor necrosis factor-α, interleukin (IL)-6, IL-10, and monocyte chemoattractant protein-1, as well as the protein levels of p50, p65, and p-p65 in the kidney of CRF rats. 28352125 2017
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 AlteredExpression disease BEFREE Osthole treatment significantly attenuated the protein expression of transforming growth factor‑β1 (TGF‑β1), reduced monocyte chemoattractant protein‑1 activity and increased the phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt) ratio in CRF rats. 28765904 2017
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 AlteredExpression disease BEFREE MCP-1 expression in endothelial cells treated with uremic serum from ESRD patients with hypertension only was significantly increased compared with its expression in other cohorts. 31312972 2019
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.600 GeneticVariation disease BEFREE Comparison of the <i>MCP-1</i> gene polymorphism distribution in ESRD patients with various primary diseases leading to ESRD did not show any significant differences. 31847640 2019