|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The MCP-1 -2518G allele may be contributing to atherosclerosis and CAD by conferring an increased risk to metabolic syndrome and/or obesity.
|
19450143 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Positive genetic correlations were seen between CRP, leptin, MCP-1 and obesity traits, and negative genetic correlations with adiponectin, ICAM-1 and TGF-beta1.
|
18848781 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, the findings suggest that MCP-1 may be involved in obesity-related health complications and support the hypothesis that weight loss is beneficial by improving the low-grade inflammation observed in obesity.
|
15520826 |
2005 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Given the association between obesity, chronic low-grade inflammation, and insulin resistance, we examined the effects of alpha- and gamma-MG on markers of inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes treated with lipopolysaccharide (LPS). alpha- and gamma-MG decreased the induction by LPS of inflammatory genes, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, monocyte chemoattractant protein-1, and Toll-like receptor-2.
|
19403722 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Levels of hs-CRP (P=0.029), TNF-α (P=0.036), IL-6 (P=0.042), oxidized LDL (P=0.036), and MCP-1 (P=0.039) increased from the MHNO to MHO to MONO to MOO phenotypes.
|
25478993 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
These observations demonstrate similar interstitial concentrations and a differential gene response to hyperinsulinemia of MCP-1 in the SCAAT from L and OB individuals.
|
17456576 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
This article underlines the significance and involvement of the chemokine MCP-1 in the development of obesity, type 2 diabetes, and diabetic complications, with an emphasis on the role of plant metabolites in the regulation of this chemokine and thus the role in the prevention or therapy of diabetes.
|
28266270 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Combined treatment of PA and LPS in RAW264.7 cells mimics the situation of diabetes with obesity that has higher level of PA and LPS, MAPK/TLR4/ MCP-1 might be potential therapeutic targets for diabetes with obesity.
|
30909920 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
To further understand the characteristics of inflammation in the ovaries of obese women we analysed a panel of cytokines (IL6, IL10 and TNFα), adipokines (adiponectin, leptin and monocyte chemotactic factor 1 (MCP-1)) and acute phase proteins (C-Reactive Protein (CRP) and sICAM-1) in the ovarian follicular fluid obtained at oocyte aspiration from women (n = 48) who were lean, overweight or obese.
|
30174020 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
It is not known to what extent inflammation precedes the development of obesity.MethodsIn a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age.ResultsAmong children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14.
|
29244802 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with elevated monocyte chemoattractant protein-1 (MCP-1), a proinflammatory chemokine related to diabetes and cardiovascular disease.
|
25994074 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, the level of urinary monocyte chemoattractant protein‑1 (u‑MCP‑1) was increased in the participants with obesity, and it was positively correlated with free fatty acid (FFA), UACR and u‑NGAL.
|
30535458 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mouse and human skeletal muscles gain a distinct population of inflammatory macrophages upon HFD or obesity, linked to insulin resistance in humans and CCL2 availability in mice.
|
24030890 |
2014 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Arteriovenous studies confirmed in vivo RANTES and IL-6 release in adipose tissue of lean and obese subjects and release of MCP-1 in obesity.
|
19240255 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The hypertrophied white adipose tissue (WAT) during human obesity produces inflammatory mediators, including cytokines (IL-6 and TNFα) and chemokines ([C-C motif] chemokine ligand 2 and IL-8).
|
23372021 |
2013 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 in obesity and type 2 diabetes. Insulin sensitivity study.
|
17372317 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that obesity promotes CNS inflammation in EAE through IL-6 and CCL-2 mediated the inflammatory cells infiltration.
|
31507583 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to identify loci regulating serum MCP-1 in obese Hispanic children from the Viva La Familia Study.
|
23017229 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor [PDGF-BB] and insulin-like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non-IR) and 32 controls.
|
30350467 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
RANTES and MCP-1 serum levels were increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with rimonabant, which slowed weight gain in rats with the metabolic syndrome.
|
18469848 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overall, our findings support a model in which elevated FFAs in obesity create a milieu for TNF-α to trigger CCL2 production via the TLR4/TRIF/IRF3 signaling cascade, representing a potential contribution of FFAs to metabolic inflammation.
|
29632147 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude hypoxia or obesity induces release of inflammatory TNFα and MCP-1 from mice primary adipocytes but the two environmental conditions do not synergize to worsen macrophage signal transduction or insulin responsiveness.
|
31677795 |
2020 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity increases the expression of leptin and other cytokines, as well as some macrophage and inflammatory markers, and decreases adiponectin expression in adipose tissue.A number of cytokines, e.g. tumour necrosis factor alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1), and some pro-inflammatory interleukins, leuckocyte antigens, chemochines, surface adhesion molecules and metalloproteases are up-regulated whereas other factors are down-regulated.
|
17922949 |
2007 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Insulin-stimulated total glucose disposal (TGD), plasma FFA species, muscle insulin signalling, IBα protein, c-Jun phosphorylation, inflammatory gene (toll-like receptor 4 and monocyte chemotactic protein 1) expression, and ceramide and diacylglycerol (DAG) content were measured in muscle from a group of obese and T2DM subjects before and after administration of the antilipolytic drug acipimox for 7 days, and the results were compared to lean individuals.
|
23529132 |
2013 |