|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, the findings suggest that MCP-1 may be involved in obesity-related health complications and support the hypothesis that weight loss is beneficial by improving the low-grade inflammation observed in obesity.
|
15520826 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Thus the augmented MCP-1 expression by ANG II in preadipocytes may provide a new link between obesity and cardiovascular disease.
|
16705055 |
2006 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice.
|
16691291 |
2006 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity increases the expression of leptin and other cytokines, as well as some macrophage and inflammatory markers, and decreases adiponectin expression in adipose tissue.A number of cytokines, e.g. tumour necrosis factor alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1), and some pro-inflammatory interleukins, leuckocyte antigens, chemochines, surface adhesion molecules and metalloproteases are up-regulated whereas other factors are down-regulated.
|
17922949 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
These observations demonstrate similar interstitial concentrations and a differential gene response to hyperinsulinemia of MCP-1 in the SCAAT from L and OB individuals.
|
17456576 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 in obesity and type 2 diabetes. Insulin sensitivity study.
|
17372317 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Positive genetic correlations were seen between CRP, leptin, MCP-1 and obesity traits, and negative genetic correlations with adiponectin, ICAM-1 and TGF-beta1.
|
18848781 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Insulin increases CCL2 expression in adipose tissue and in serum more in insulin-resistant obese than in insulin-sensitive lean mice, but whether this is true in humans is unknown.
|
18270300 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
During the expansion of adipose tissue mass in obesity there is a major inflammatory response in the tissue with increased expression and release of inflammation-related adipokines, including IL-6, leptin, monocyte chemoattractant protein-1 and TNF-alpha, together with decreased adiponectin production.
|
18397542 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
RANTES and MCP-1 serum levels were increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with rimonabant, which slowed weight gain in rats with the metabolic syndrome.
|
18469848 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Given the association between obesity, chronic low-grade inflammation, and insulin resistance, we examined the effects of alpha- and gamma-MG on markers of inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes treated with lipopolysaccharide (LPS). alpha- and gamma-MG decreased the induction by LPS of inflammatory genes, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, monocyte chemoattractant protein-1, and Toll-like receptor-2.
|
19403722 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The MCP-1 -2518G allele may be contributing to atherosclerosis and CAD by conferring an increased risk to metabolic syndrome and/or obesity.
|
19450143 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Arteriovenous studies confirmed in vivo RANTES and IL-6 release in adipose tissue of lean and obese subjects and release of MCP-1 in obesity.
|
19240255 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The data provide important mechanistic information on the cause of hepatic injury in obese-HCV subjects including: (1) enhanced T helper-1 cytokine response patterns-to promote hepatocellular injury; (2) increased expression of the chemokines IP-10 and MCP-1 at both the mRNA and protein levels-to enhance inflammatory cell recruitment; (3) differing localisation of these chemokines within the liver of obese-HCV versus lean-HCV subjects-implying different inducing stimuli and; (4) increased CD3 expression in the liver of obese-HCV subjects-concordant with the increased expression of T cell chemoattractants.
|
19289381 |
2010 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that obesity activates hepatocyte expression of C-C chemokine ligand 2 (CCL2/MCP-1) leading to hepatic recruitment of CCR2(+) myeloid cells that promote hepatosteatosis.
|
20103702 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to identify loci regulating serum MCP-1 in obese Hispanic children from the Viva La Familia Study.
|
23017229 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Among the adipokines analyzed, the most notable finding was a 15% lower level of monocyte chemotactic protein-1 in HT users, particularly with respect to its suggested mediator role between obesity and insulin resistance.
|
22914204 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Insulin-stimulated total glucose disposal (TGD), plasma FFA species, muscle insulin signalling, IBα protein, c-Jun phosphorylation, inflammatory gene (toll-like receptor 4 and monocyte chemotactic protein 1) expression, and ceramide and diacylglycerol (DAG) content were measured in muscle from a group of obese and T2DM subjects before and after administration of the antilipolytic drug acipimox for 7 days, and the results were compared to lean individuals.
|
23529132 |
2013 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The hypertrophied white adipose tissue (WAT) during human obesity produces inflammatory mediators, including cytokines (IL-6 and TNFα) and chemokines ([C-C motif] chemokine ligand 2 and IL-8).
|
23372021 |
2013 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mouse and human skeletal muscles gain a distinct population of inflammatory macrophages upon HFD or obesity, linked to insulin resistance in humans and CCL2 availability in mice.
|
24030890 |
2014 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Levels of hs-CRP (P=0.029), TNF-α (P=0.036), IL-6 (P=0.042), oxidized LDL (P=0.036), and MCP-1 (P=0.039) increased from the MHNO to MHO to MONO to MOO phenotypes.
|
25478993 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with elevated monocyte chemoattractant protein-1 (MCP-1), a proinflammatory chemokine related to diabetes and cardiovascular disease.
|
25994074 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The visceral adipose tissue expression levels of APN in normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels of TNF-α and MCP-1 in normal group were lower than those in obesity and T2DM groups (P < 0.01).
|
26273678 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Lower ADIPOQ and higher TNF and MCP1 mRNA expression in visceral adipose tissue may be correlated with obesity and T2DM in the Uygur population.
|
27573980 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
This article underlines the significance and involvement of the chemokine MCP-1 in the development of obesity, type 2 diabetes, and diabetic complications, with an emphasis on the role of plant metabolites in the regulation of this chemokine and thus the role in the prevention or therapy of diabetes.
|
28266270 |
2017 |