|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity increases the expression of leptin and other cytokines, as well as some macrophage and inflammatory markers, and decreases adiponectin expression in adipose tissue.A number of cytokines, e.g. tumour necrosis factor alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1), and some pro-inflammatory interleukins, leuckocyte antigens, chemochines, surface adhesion molecules and metalloproteases are up-regulated whereas other factors are down-regulated.
|
17922949 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with elevated monocyte chemoattractant protein-1 (MCP-1), a proinflammatory chemokine related to diabetes and cardiovascular disease.
|
25994074 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated to a low-grade inflammation that alters the expression of adiponectin, leptin, IL-6, Monocyte Chemotactic Protein 1 (MCP1), TRAIL, LIGHT/TNFSF14, OPG, and TNFα.
|
31130918 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obese-ALI animals, compared to Obese-SAL, exhibited increased interventricular septum thickness (<i>p</i> = 0.003) and posterior wall thickness (<i>p</i> = 0.003) and decreased pulmonary acceleration time to pulmonary ejection time ratio (<i>p</i> = 0.005); no changes in lung mechanics, IL-6, TNF-α, TGF-β, PCIII, and PCI in lung tissue; increased IL-10 levels in lung homogenate (<i>p</i> = 0.007); reduced MCP-1 expression in blood neutrophils (<i>p</i> = 0.009); decreased TNF-α expression in blood (<i>p</i> = 0.02) and BALF (<i>p</i> = 0.008) neutrophils; and increased IL-10 expression in monocytes (<i>p</i> = 0.004).
|
31275296 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 in obesity and type 2 diabetes. Insulin sensitivity study.
|
17372317 |
2007 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Among the adipokines analyzed, the most notable finding was a 15% lower level of monocyte chemotactic protein-1 in HT users, particularly with respect to its suggested mediator role between obesity and insulin resistance.
|
22914204 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Arteriovenous studies confirmed in vivo RANTES and IL-6 release in adipose tissue of lean and obese subjects and release of MCP-1 in obesity.
|
19240255 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Combined treatment of PA and LPS in RAW264.7 cells mimics the situation of diabetes with obesity that has higher level of PA and LPS, MAPK/TLR4/ MCP-1 might be potential therapeutic targets for diabetes with obesity.
|
30909920 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
During the expansion of adipose tissue mass in obesity there is a major inflammatory response in the tissue with increased expression and release of inflammation-related adipokines, including IL-6, leptin, monocyte chemoattractant protein-1 and TNF-alpha, together with decreased adiponectin production.
|
18397542 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Given the association between obesity, chronic low-grade inflammation, and insulin resistance, we examined the effects of alpha- and gamma-MG on markers of inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes treated with lipopolysaccharide (LPS). alpha- and gamma-MG decreased the induction by LPS of inflammatory genes, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, monocyte chemoattractant protein-1, and Toll-like receptor-2.
|
19403722 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, the findings suggest that MCP-1 may be involved in obesity-related health complications and support the hypothesis that weight loss is beneficial by improving the low-grade inflammation observed in obesity.
|
15520826 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In terms of therapeutic applications, implant of scaffolds designed to release resveratrol into the visceral fat decreases MCP-1 expression in mice fed a high fat diet, a molecule that drives both local and systemic inflammation during obesity.
|
30462474 |
2018 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Insulin increases CCL2 expression in adipose tissue and in serum more in insulin-resistant obese than in insulin-sensitive lean mice, but whether this is true in humans is unknown.
|
18270300 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Insulin-stimulated total glucose disposal (TGD), plasma FFA species, muscle insulin signalling, IBα protein, c-Jun phosphorylation, inflammatory gene (toll-like receptor 4 and monocyte chemotactic protein 1) expression, and ceramide and diacylglycerol (DAG) content were measured in muscle from a group of obese and T2DM subjects before and after administration of the antilipolytic drug acipimox for 7 days, and the results were compared to lean individuals.
|
23529132 |
2013 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
It is not known to what extent inflammation precedes the development of obesity.MethodsIn a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age.ResultsAmong children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14.
|
29244802 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Levels of hs-CRP (P=0.029), TNF-α (P=0.036), IL-6 (P=0.042), oxidized LDL (P=0.036), and MCP-1 (P=0.039) increased from the MHNO to MHO to MONO to MOO phenotypes.
|
25478993 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Lower ADIPOQ and higher TNF and MCP1 mRNA expression in visceral adipose tissue may be correlated with obesity and T2DM in the Uygur population.
|
27573980 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, the level of urinary monocyte chemoattractant protein‑1 (u‑MCP‑1) was increased in the participants with obesity, and it was positively correlated with free fatty acid (FFA), UACR and u‑NGAL.
|
30535458 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mouse and human skeletal muscles gain a distinct population of inflammatory macrophages upon HFD or obesity, linked to insulin resistance in humans and CCL2 availability in mice.
|
24030890 |
2014 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overall, our findings support a model in which elevated FFAs in obesity create a milieu for TNF-α to trigger CCL2 production via the TLR4/TRIF/IRF3 signaling cascade, representing a potential contribution of FFAs to metabolic inflammation.
|
29632147 |
2018 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
OVX and HF significantly reduced plasma levels of nitrate/nitrite (NOx), and mice developed obesity with visceral hypertrophic adipocytes and increased transcriptional levels of monocyte chemoattractant protein-1, TNF-α, and IL-6 in visceral fat tissues.
|
28196859 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Positive genetic correlations were seen between CRP, leptin, MCP-1 and obesity traits, and negative genetic correlations with adiponectin, ICAM-1 and TGF-beta1.
|
18848781 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
RANTES and MCP-1 serum levels were increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with rimonabant, which slowed weight gain in rats with the metabolic syndrome.
|
18469848 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that obesity promotes CNS inflammation in EAE through IL-6 and CCL-2 mediated the inflammatory cells infiltration.
|
31507583 |
2019 |