|
Ascites
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
DHMEQ suppressed the production of TNF-α, IL-6, and MCP-1 from PECs.
|
30950670 |
2020 |
|
Retinitis Pigmentosa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with those in the control group, the aqueous humor levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-(IL-)8, interferon gamma-induced protein (IP)-10, hepatocyte growth factor (HGF), platelet-derived growth factor AA (PDGF-AA), matrix metalloproteinase-2 (MMP-2), MMP3, MMP-7, MMP-8, plasminogen activator inhibitor-1 (PAI-1), and thrombospondin-2 (TSP-2) in the RP group increased significantly (P < 0.01).
|
31810025 |
2020 |
|
Parkinsonian Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Elevated levels of pro-inflammatory RANTES or MCP-1 and decreased levels of anti-inflammatory IL-10 were found to associate with Parkinsonism and a more rapid disease progression, indicated by longitudinal measurements of either MMSE or ADCS-ADL decline.
|
31559531 |
2020 |
|
Secondary malignant neoplasm of omentum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that MCP-1 produced by omental adipocytes binding to its cognate receptor CCR-2 on ovarian cancer cells facilitates migration and omental metastasis by activating the PI3K/AKT/mTOR pathway and its downstream effectors HIF-1α and VEGF-A in cell lines, xenografts, and transgenic murine models.
|
31705064 |
2020 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Urinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis.
|
30380100 |
2020 |
|
Locally Recurrent Malignant Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High CCL2 expression was highly associated with poorer locoregional recurrence free survival, progression free survival and overall survival in patients with newly diagnosed NPC.
|
31604115 |
2020 |
|
Congenital Abnormality
|
0.010 |
AlteredExpression
|
group |
BEFREE |
ETA significantly inhibited increases in body weight and androgen, TNF-α, and MCP-1 levels, excessive recruitment of lipid droplets, altered levels of pre-adipose differentiation markers, and abnormal development of follicles.
|
31170164 |
2019 |
|
Alveolar Bone Loss
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, manipulation of endogenous M2 phenotype macrophages with CCL2 MPs decreased the M1 phenotype:M2 phenotype ratio and prevented alveolar bone loss in mouse periodontitis models.
|
30392438 |
2019 |
|
Anemia of chronic disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Targeting the CCL2/CCR2 signaling might be beneficial for the treatment of the itch and pain sensations accompanying ACD in humans.
|
30981714 |
2019 |
|
Aortic Valve Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cardiac sST2 inversely correlated with MFN-1 levels and positively associated with IL-6 and CCL-2 in myocardial biopsies from AS patients.<b>Conclusions:</b> sST2 affected mitochondrial fusion in human cardiac fibroblasts, increasing oxidative stress production and inflammatory markers secretion.
|
31285364 |
2019 |
|
Arthritis, Psoriatic
|
0.010 |
Biomarker
|
disease |
BEFREE |
In multivariate analysis, COMP (OR 1.24, 95% CI 1.06 to 1.46), resistin (OR 1.26, 95% CI 1.07 to 1.48), MCP-1 (OR 1.10, 95% CI 0.07 to 1.48) and NGF (OR<0.001, 95% CI <0.001 to 0.25) were found to be independently associated with PsA versus OA.
|
30910989 |
2019 |
|
Back Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In female DDD patients, IL-8 and MCP1 concentrations in serum were associated with increased intensity of back pain.
|
30248387 |
2019 |
|
Coughing
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Serum levels of Tumor Necrosis Factor-α (TNF-α), Monocyte chemotactic protein-1 (MCP-1), Vascular endothelial growth factor (VEGF), Epidermal growth factor (EGF), forced expiratory volume-one second (FEV<sub>1</sub>) and respiratory symptoms including; Chest wheeze (CW), night wheeze (NW), night cough (NC) and cough and wheeze during exercise (ECW) were assessed at the baseline (step 0), one and two months after starting treatment (step I and II, respectively).
|
30961947 |
2019 |
|
Cystitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Urinary markers that best differentiated pyelonephritis from cystitis included chemokine (C-X-C motif) ligand (CXCL)1, CXCL9, CXCL12, C-C motif chemokine ligand 2, INF γ, and IL-15.
|
30905425 |
2019 |
|
Fuchs' heterochromic cyclitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<i>Conclusion:</i> In our experiments, glaucoma in FUS patients was associated with low levels of MCP-1 and MMP-9 in the AH, while expression of MMP-2, MMP-3, and TGFβ-1 increased.
|
31268809 |
2019 |
|
Glaucoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<i>Conclusion:</i> In our experiments, glaucoma in FUS patients was associated with low levels of MCP-1 and MMP-9 in the AH, while expression of MMP-2, MMP-3, and TGFβ-1 increased.
|
31268809 |
2019 |
|
Hamartoma Syndrome, Multiple
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrated that PCCC-CDs significantly inhibited the kidney dysfunction (reduced serum creatinine (SCR), blood urea nitrogen (BUN), urinary total protein (UTP), and microalbuminuria (MALB) concentrations) and the production of chemoattractant (monocyte chemotactic protein 1 (MCP-1)), proinflammatory cytokines (interleukin (IL)-1β), and anti-inflammatory cytokine (IL-10) in response to intraperitoneal injection of D. acutus venom.
|
31845094 |
2019 |
|
Type II Mucolipidosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Combination treatment also inhibited IgE and CCL2 levels in ICD mice.
|
31454521 |
2019 |
|
Disruptive, Impulse Control, and Conduct Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Combination treatment also inhibited IgE and CCL2 levels in ICD mice.
|
31454521 |
2019 |
|
Impulsive Behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
GABA<sub>A</sub>R α2-activated neuroimmune signal controls binge drinking and impulsivity through regulation of the CCL2/CX3CL1 balance.
|
31030249 |
2019 |
|
Polycystic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
To test whether the absence of MCP-1 lowers renal macrophage concentration and slows disease progression, we generated genetic knockout (KO) of MCP-1 in a mouse model of PKD [congenital polycystic kidney (<i>cpk</i>) mice].
|
31091126 |
2019 |
|
Marijuana Abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
An exploratory linear regression model was built including clinical (age, sex, ethnicity, cardiovascular risk factors, body mass index, low CD4 defined as ≤200 cells/μl, leucocytes, lymphocytes, platelet, antiretroviral therapy), behavioral (tobacco and marijuana smoking, alcohol use and physical activity) and biomarker (CRP, TNF-α, IL-8, Il-10 and MCP-1) to investigate association with continuous PCSK9 levels.
|
30827714 |
2019 |
|
neurofibroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although STAT3 inhibition downregulated the chemokines CCL2 and CCL12, which can signal through CCR2 to recruit macrophages to peripheral nerves, deletion of Ccr2 did not improve survival or reduce macrophage numbers in neurofibroma-bearing mice.
|
30542122 |
2019 |
|
Disorder of the optic nerve
|
0.010 |
Biomarker
|
group |
BEFREE |
These results indicate that intravitreal injection of 2D-MSCs is a promising therapeutic strategy for retinal pathological diseases characterized by the loss of RGCs and open the door for the application of SCGF-β, HGF, and MCP-1 in the treatment of optic nerve diseases.
|
31202832 |
2019 |
|
Paget Disease Extramammary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IHC analyses revealed increased numbers of PD-L1<sup>+</sup> , PD-1<sup>+</sup> , CD163<sup>+</sup> M2 macrophages, Iba1<sup>+</sup> macrophages, and Foxp3<sup>+</sup> Tregs that were associated with high LDHA levels in EMPD. ddPCR demonstrated that multiple cytokines including IL-4, IL-6, IL-10, TGF-β, and CCL-2 were upregulated and associated with high LDHA levels in EMPD.
|
31838771 |
2019 |