CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Disease: Heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure 		0.560 Biomarker disease BEFREE An anti-MCP-1 gene therapy can be a useful novel strategy for preventing post-MI heart failure. 14517168 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.560 Biomarker disease BEFREE As MCP-1 plays an important role in cardiac fibrosis (CF) and heart failure (HF), we investigated the role of Cytl1 in a mouse model of CF and HF. 27835665 2016
CUI: C0018801
Disease: Heart failure
Heart failure 		0.560 AlteredExpression disease BEFREE Cardiomyocyte-targeted expression of MCP-1 in mice caused death by heart failure at 6 months of age. 16574901 2006
CUI: C0018801
Disease: Heart failure
Heart failure 		0.560 AlteredExpression disease BEFREE Induction of brain natriuretic peptide and monocyte chemotactic protein-1 gene expression by oxidized low-density lipoprotein: relevance to ischemic heart failure. 21900689 2012
CUI: C0018801
Disease: Heart failure
Heart failure 		0.560 AlteredExpression disease BEFREE Moreover, cardiomyocyte-specific AOX expression resulted in exacerbation of Mcp1-induced heart failure, and failed to rescue a second cardiomyopathy model directly involving loss of cIV. 31484989 2019
CUI: C0018801
Disease: Heart failure
Heart failure 		0.560 Biomarker disease RGD Our novel findings of increased cardiac CNTF and cardiopulmonary MCP-1 mRNA indicate a role for these factors in the pathogenesis of HF. 12950323 2003
CUI: C0018801
Disease: Heart failure
Heart failure 		0.560 GeneticVariation disease BEFREE This novel hypoxia-induced miR-146b-TRAF6-IL-6/CCL2(MCP-1) axis likely drives cardiac fibrosis and dysfunction, and may lead to heart failure. 31338525 2019
CUI: C0018801
Disease: Heart failure
Heart failure 		0.560 Biomarker disease CTD_human TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure. 29959987 2018