CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021368
Disease: Inflammation
Inflammation
0.540 Biomarker phenotype CTD_human IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1), quantified by ELISA and by gene expression analysis using a low-density array allowing the evaluation of expression level for 46 genes relevant of the intestinal inflammation and functional metabolism. 20816778 2010
CUI: C0021368
Disease: Inflammation
Inflammation
0.540 GeneticVariation phenotype LHGDN Inheritance of the -2518 MCP-1 G allele, which appears to affect hepatic MCP-1 expression, may predispose HCV patients to more severe hepatic inflammation and fibrosis. 14517792 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.540 Biomarker phenotype LHGDN Therefore, MCP-1 may represent a molecular link in the negative cross-talk between adipose tissue and skeletal muscle assigning a completely novel important role to MCP-1 besides inflammation. 16439461 2006
CUI: C0021368
Disease: Inflammation
Inflammation
0.540 Biomarker phenotype LHGDN Monocyte chemotactic protein-1 is thus a therapeutic target, and may represent an important factor linking adipose tissue inflammation, obesity and type 2 diabetes. 17495598 2007
CUI: C0021368
Disease: Inflammation
Inflammation
0.540 Biomarker phenotype CTD_human Lidocaine attenuates monocyte chemoattractant protein-1 production and chemotaxis in human monocytes: possible mechanisms for its effect on inflammation. 14570645 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.540 Biomarker phenotype CTD_human Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice. 19762220 2010
CUI: C0021368
Disease: Inflammation
Inflammation
0.540 Biomarker phenotype LHGDN The results suggest that HHV-8-induced MCP-1 may play an important role in promoting inflammation and pathogenic angiogenesis typical of HHV-8-associated lesions. 17138827 2007
CUI: C0021368
Disease: Inflammation
Inflammation
0.540 Biomarker phenotype RGD The increased BP was related to increased aortic inflammation (tumor necrosis factor [TNF]-α; nitric oxide synthase [iNOS], COX-2 and MCP-1 protein expression) and elevated angiotensin II levels in alcohol-treated group compared to control. 20921064 2011