CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.560 Biomarker disease BEFREE Monocyte chemoattractant protein-1 (MCP-1) plays a role in the pathogenesis of lung inflammation and infection. 31064097 2019
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.560 Biomarker disease BEFREE PAR(1) knockout mice are protected from bleomycin-induced lung inflammation and fibrosis and this protection is associated with marked attenuation in CCL2 induction. 19060230 2009
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.560 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.560 Biomarker disease BEFREE A significant increase in the number of alveolar macrophages and infiltrating neutrophils in the lungs and elevation in monocyte chemoattractant protein-1 (MCP-1) in BALF suggested the induction of pulmonary inflammation in the silica exposed rats. 28317464 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.560 Biomarker disease CTD_mouse Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.560 Biomarker disease BEFREE NLE inhibited the recruitment of inflammatory cells and the expression of monocyte chemoattractant protein-1 (MCP-1) in the lungs of mice with CS- and LPS-induced pulmonary inflammation. 29039495 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.560 AlteredExpression disease BEFREE Aging can increase the expression of MCP-1,CINC-1 and CINC-2α in patients with pneumonia, which may lead to increased risk of pneumonia in the elderly. 29312554 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.560 AlteredExpression disease BEFREE Attenuation of lung inflammation indicative of acute lung injury, such as alveolar hemorrhage, interstitial thickening, and the presence of alveolar exudate, together with reduced levels of the inflammatory mediators TNFα, IL-1β, IL-6, KC, and MCP-1, strongly suggests amelioration of the pathological immune response in the lungs to promote resolution of the infection. 29516781 2018