CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 GeneticVariation disease BEFREE Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with IHD. 15245376 2004
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 GeneticVariation disease BEFREE Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities. 25413568 2015
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 GeneticVariation disease BEFREE The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group of healthy subjects. 19639050 2009
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease RGD Neutralization of MCAF/MCP-1 is beneficial by preventing reperfusion injury in a rat model of myocardial ischemia and reperfusion. 10068207 1999
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease RGD Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. 16297799 2005
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease BEFREE However, the gene expression changes caused by signal transduction, triggered by MCP-1 binding to its receptor CCR2, and their possible role in the development of IHD are not understood. 16574901 2006
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease BEFREE Recent studies have indicated that monocyte chemoattractant protein-1 (MCP-1) plays an important role in the initiation and progression of ischaemic heart disease. 31077149 2019