Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Vehicle-treated ApoE(-/-) mice exhibited significant increases in aortic inflammation and atherosclerosis as well as enhanced expression of HMGB1, RAGE, VCAM-1, and MCP-1 in aortic tissues as compared to the wild-type mice.
|
23564080 |
2013 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The interaction between monocyte chemoattractant protein-1 and chemokine receptor 2 (CCR2) may be the cause of atherosclerosis, obesity, and insulin resistance.
|
29251559 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 (MCP-1) is an important chemokine at multiple phases of atherosclerosis in animals, but human studies are few and inconsistent.
|
25786118 |
2015 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, the authors examined whether the organic germanium suppresses the MCP-1-induced monocyte migration in vitro and the development of atherosclerosis in WHHL rabbits in vivo.
|
12548076 |
2003 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in hypercholesterolemic mice.
|
14739122 |
2004 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies in animals have shown that resistance to atherosclerosis in spite of hypercholesterolemia is affected by factors such as high-density lipoprotein (HDL) phospholipids that enhance reverse cholesterol transport, non-responsiveness to induction or lack of monocyte chemotactic protein-1 (MCP-1), C-C chemokine receptor 2 (CCR2), macrophage colony stimulating factor (MCSF), or vascular cell adhesion molecule-1 (VCAM-1).
|
11755917 |
2002 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MCP-1 -2518G allele may be contributing to atherosclerosis and CAD by conferring an increased risk to metabolic syndrome and/or obesity.
|
19450143 |
2009 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Many studies in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI).
|
28566450 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke.
|
31476962 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in obesity-associated chronic inflammation, insulin resistance, and atherosclerosis.
|
17456576 |
2007 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CCL2 expression was associated with a significant predictive value of atherosclerosis.
|
31739217 |
2020 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest a coordinated role between CCL2 and PON1 that may be detected in blood with simple measurements and may represent an indicator of the extent of atherosclerosis.
|
21663591 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma MCP-1 concentration is genetically determined and associated with age and smoking habit and it also correlates with subclinical atherosclerosis in HIV-infected patients.
|
16445900 |
2006 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 (MCP-1) is a potent agonist for mononuclear leukocytes and has been implicated in the pathogenesis of atherosclerosis and granulomatous lung disease.
|
9366570 |
1997 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, in this study, cPA had no effect on the expression and secretion of C-C motif chemokine 2 (CCL-2), a chemokine that is also linked to inflammatory responses and atherosclerosis.
|
29990859 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings clearly indicate the role of C/EBPs in the mechanism of upregulation of CCL2, an inflammation-related protein, observed in the hyperinsulinaemic state, which may initiate the process of atherosclerosis.
|
17180354 |
2007 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes.
|
19781803 |
2009 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This trial evaluated the potential impacts of saffron aqueous extract (SAE) and its main carotenoid on some of the atherosclerosis-related gene expression and serum levels of oxidized low-density cholesterol (ox-LDL) and Monocyte chemoattractant protein 1 (MCP-1) in patients with coronary artery disease (CAD).
|
31797473 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory cytokine that plays a key role in the development of atherosclerosis.
|
31388753 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), monocyte chemoattractant protein-1 (MCP-1) and apolipoprotein E (ApoE) genes appear to be a genetic risk factor for atherosclerosis.
|
19148342 |
2009 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to greater levels of systemic inflammation, heightened monocyte activation (sCD163, CCL2) may contribute to the burden of atherosclerosis among HIV-infected persons.
|
30946765 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 (MCP-1), as a critical factor for monocyte infiltration, is known to play a role in the development of atherosclerosis.
|
26354107 |
2016 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Based on our findings, we suggest that Nrf2-dependent HO-1 expression induced by HA inhibits MCP-1 secretion, VCAM-1 expression and NF-kappaB activation associated with vascular injury and inflammation in atherosclerosis.
|
16246346 |
2006 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In summary, ghrelin can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 expression at an advanced stage of atherosclerosis in rabbits.
|
28189525 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this work, we synthesized monocyte-targeting iron oxide magnetic nanoparticles (MNPs), which were incorporated with the peptides derived from the chemokine receptor C-C chemokine receptor type 2 (CCR2)-binding motif of monocytes chemoattractant protein-1 (MCP-1) as a diagnostic tool for potential atherosclerosis.
|
29795012 |
2018 |