|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that obesity activates hepatocyte expression of C-C chemokine ligand 2 (CCL2/MCP-1) leading to hepatic recruitment of CCR2(+) myeloid cells that promote hepatosteatosis.
|
20103702 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Given the association between obesity, chronic low-grade inflammation, and insulin resistance, we examined the effects of alpha- and gamma-MG on markers of inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes treated with lipopolysaccharide (LPS). alpha- and gamma-MG decreased the induction by LPS of inflammatory genes, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, monocyte chemoattractant protein-1, and Toll-like receptor-2.
|
19403722 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The MCP-1 -2518G allele may be contributing to atherosclerosis and CAD by conferring an increased risk to metabolic syndrome and/or obesity.
|
19450143 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Arteriovenous studies confirmed in vivo RANTES and IL-6 release in adipose tissue of lean and obese subjects and release of MCP-1 in obesity.
|
19240255 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Positive genetic correlations were seen between CRP, leptin, MCP-1 and obesity traits, and negative genetic correlations with adiponectin, ICAM-1 and TGF-beta1.
|
18848781 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Insulin increases CCL2 expression in adipose tissue and in serum more in insulin-resistant obese than in insulin-sensitive lean mice, but whether this is true in humans is unknown.
|
18270300 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
During the expansion of adipose tissue mass in obesity there is a major inflammatory response in the tissue with increased expression and release of inflammation-related adipokines, including IL-6, leptin, monocyte chemoattractant protein-1 and TNF-alpha, together with decreased adiponectin production.
|
18397542 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
RANTES and MCP-1 serum levels were increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with rimonabant, which slowed weight gain in rats with the metabolic syndrome.
|
18469848 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity increases the expression of leptin and other cytokines, as well as some macrophage and inflammatory markers, and decreases adiponectin expression in adipose tissue.A number of cytokines, e.g. tumour necrosis factor alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1), and some pro-inflammatory interleukins, leuckocyte antigens, chemochines, surface adhesion molecules and metalloproteases are up-regulated whereas other factors are down-regulated.
|
17922949 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
These observations demonstrate similar interstitial concentrations and a differential gene response to hyperinsulinemia of MCP-1 in the SCAAT from L and OB individuals.
|
17456576 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 in obesity and type 2 diabetes. Insulin sensitivity study.
|
17372317 |
2007 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Thus the augmented MCP-1 expression by ANG II in preadipocytes may provide a new link between obesity and cardiovascular disease.
|
16705055 |
2006 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice.
|
16691291 |
2006 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, the findings suggest that MCP-1 may be involved in obesity-related health complications and support the hypothesis that weight loss is beneficial by improving the low-grade inflammation observed in obesity.
|
15520826 |
2005 |