CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group. 18617279 2009
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE Our data demonstrate that MCP-1 -2518 A>G polymorphism is not associated with premature CAD in Turkish patients. 18651322 2008
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE Controversial results regarding the association of the -2518G/A polymorphism of the MCP-1 gene with coronary artery disease (CAD) have been reported. 18230355 2008
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease LHGDN This study demonstrates for the first time that the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and demonstrates an apparent interaction with CAD risk factor burden. 16934270 2007
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease LHGDN These findings suggest that restenosis development after PCI in patients with coronary artery disease may involve the participation of MCP-1 after PCI, and adiponectin incompletely prevent this MCP-1-dependent restenosis. 17486299 2007
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE In this study, in order to determine the role of CCR2, a receptor for MCP-1, in the development of CAD, we initially sequenced and identified the genetic variants of CCR2 using 24 unrelated Korean individuals' DNA samples. 17482150 2007
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE This study demonstrates for the first time that the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and demonstrates an apparent interaction with CAD risk factor burden. 16934270 2007
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease CTD_human This study demonstrates for the first time that the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and demonstrates an apparent interaction with CAD risk factor burden. 16934270 2007
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction. 16164699 2005
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease BEFREE MCP-1 G-2518, SDF-1beta A801, and CCR5 Delta32 were not associated with CAD. 15302103 2004
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE Currently, there is conflicting evidence regarding an association between polymorphisms in CCR2/MCP-1 and CCR5/RANTES and coronary artery disease. 15017357 2004
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 AlteredExpression disease BEFREE In this respect, increased expression of MCP-1 and the corresponding receptor CCR2 have been demonstrated in renal transplant rejection and coronary artery disease. 12239249 2002
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 Biomarker disease CTD_human The MCP-1 -2518G variant in homozygous form appears as a genetic risk factor for severe CAD. 11500196 2001
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.400 GeneticVariation disease BEFREE The MCP-1 -2518G variant in homozygous form appears as a genetic risk factor for severe CAD. 11500196 2001