|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that obesity promotes CNS inflammation in EAE through IL-6 and CCL-2 mediated the inflammatory cells infiltration.
|
31507583 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor [PDGF-BB] and insulin-like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non-IR) and 32 controls.
|
30350467 |
2019 |
|
Coronary Arteriosclerosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females.
|
30557342 |
2018 |
|
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hematoxylin and eosin staining indicated that the infiltration of macrophages was significantly decreased in the high-dose TS group when compared with the DN group (P<0.01). mRNA and protein expression levels of MCP-1 and MIF in the high-dose TS group were significantly decreased when compared with the DN group (P<0.05).
|
29434819 |
2018 |
|
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the relationship between miR-374a and MCP-1 in DN is unknown.
|
30147653 |
2018 |
|
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate the performance of urinary EGF, MCP-1 or their ratio in predicting rapid decline of GFR in a cohort of Type 2 diabetic patients (T2DM) with diabetic kidney disease (DKD).
|
30241508 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In comparison, during the 9-year follow-up, the proband showed persistent hypertension (from 125/85 to 140/95 mm Hg), low total kidney volume (75 and 61% of median ADPKD), and a ninefold increase in urine MCP-1.
|
30368514 |
2018 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In terms of therapeutic applications, implant of scaffolds designed to release resveratrol into the visceral fat decreases MCP-1 expression in mice fed a high fat diet, a molecule that drives both local and systemic inflammation during obesity.
|
30462474 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
To further understand the characteristics of inflammation in the ovaries of obese women we analysed a panel of cytokines (IL6, IL10 and TNFα), adipokines (adiponectin, leptin and monocyte chemotactic factor 1 (MCP-1)) and acute phase proteins (C-Reactive Protein (CRP) and sICAM-1) in the ovarian follicular fluid obtained at oocyte aspiration from women (n = 48) who were lean, overweight or obese.
|
30174020 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
It is not known to what extent inflammation precedes the development of obesity.MethodsIn a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age.ResultsAmong children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14.
|
29244802 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overall, our findings support a model in which elevated FFAs in obesity create a milieu for TNF-α to trigger CCL2 production via the TLR4/TRIF/IRF3 signaling cascade, representing a potential contribution of FFAs to metabolic inflammation.
|
29632147 |
2018 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This study was aimed to determine the profiles of serum cytokines (IL-1β, TNF-α, IL-4, IL-5) and chemokines (MCP-1: monocyte chemoattract protein-1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non-asthmatic background with bacterial, viral or mixed acute respiratory infection.
|
28168862 |
2017 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Air-liquid interface cultures of human bronchial epithelial cells (HBEC) of control subjects (cHBEC) or severe asthma patients (saHBEC) were co-cultured with monocyte-derived dendritic cells (moDC).Increased release of CXCL8, TSLP and IL-33 from saHBEC contrasted with cHBEC producing CXCL10 and CCL2.
|
28275176 |
2017 |
|
Coronary Arteriosclerosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum concentrations of MCP-1 and IL-6 in combination predict the presence of coronary artery disease and mortality in subjects undergoing coronary angiography.
|
28534120 |
2017 |
|
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Ad-SOCS2 infection alleviated STZ-induced renal injury and pathological changes and inhibited STZ-induced IL-6, IL-1β and MCP-1 generation and activation of the TLR4/NF-κB pathway in DN rats.
|
29207635 |
2017 |
|
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cilostazol demonstrated renoprotective effects in patients with diabetic nephropathy by reducing serum soluble adhesion molecule-1 and monocyte chemoattractant protein-1.
|
28293857 |
2017 |
|
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Unexpectedly, NaW further induced IL-6, IL-8, and MCP-1 secretion in both N- and D-RPTEC, together with lower levels of IL-1 RA, IL-4, IL-10, and GM-CSF, suggesting that it may contribute to the extent of renal damage/repair during DKD.
|
27186953 |
2017 |
|
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.
|
28837800 |
2017 |
|
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
The activation of TLRs stimulates the expression of several inflammatory cytokines and chemokines such as CCL2 and tumor necrosis factor (TNF)-α, which are associated with the progression of diabetic nephropathy.
|
28933050 |
2017 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Since MCP-1 levels were similar in both RH and HTN subjects and decreased in hypertensive patients with existing LVH, our study suggests a possible downregulation in MCP-1 levels in hypertensive individuals with LVH, regardless of hypertension strata.
|
28380135 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
To better understand hypertension development, the authors determined whether monocyte chemoattractant protein-1 (MCP-1) is associated with arterial stiffness (pulse wave velocity [PWV]) and carotid intima-media wall thickness (cIMT) in a young apparently healthy black and white population (N=403, aged 20-30 years).
|
27453537 |
2017 |
|
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Osthole treatment significantly attenuated the protein expression of transforming growth factor‑β1 (TGF‑β1), reduced monocyte chemoattractant protein‑1 activity and increased the phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt) ratio in CRF rats.
|
28765904 |
2017 |
|
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, H<sub>2</sub>S decreased the expression levels of tumor necrosis factor-α, interleukin (IL)-6, IL-10, and monocyte chemoattractant protein-1, as well as the protein levels of p50, p65, and p-p65 in the kidney of CRF rats.
|
28352125 |
2017 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Lower ADIPOQ and higher TNF and MCP1 mRNA expression in visceral adipose tissue may be correlated with obesity and T2DM in the Uygur population.
|
27573980 |
2017 |