CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.360 GeneticVariation disease BEFREE This meta-analysis showed that the MCP-1-2518-A allele confers susceptibility to Asian patients with RA and European patients with CD. 26318885 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.360 GeneticVariation disease BEFREE Subgroup analysis by disease subtype suggested the -A2518G polymorphism in MCP-1 had a protective effect against Crohn's disease (OR 0.69, 95% CI 0.58-0.81, P = 0.000), but not against ulcerative colitis. 25620350 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.360 Biomarker disease CTD_human Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. 21829567 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.360 AlteredExpression disease BEFREE MCP-1 plasma levels in CD and UC patients were similar to those in HCs (P=0.38), irrespective of disease activity, or MCP-1 genotypes. 20125127 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.360 Biomarker disease BEFREE Resistin, interleukin-6, and monocyte chemotactic protein-1 were not specifically induced in CD but were associated with unspecific inflammation. 16775490 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.360 Biomarker disease BEFREE MCP-1 concentration in tissue homogenates was analyzed in mucosal biopsy specimens of 31 patients with Crohn's disease and 48 controls by enzyme-linked immunosorbent assay, and the correlation with an endoscopic macroscopic score was analyzed. 12904997 2003
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.360 Biomarker disease BEFREE In contrast, inflamed mucosa from patients with ulcerative colitis or Crohn's disease contained multiple cells immunoreactive for MCP-1, including spindle cells, mononuclear cells, and endothelial cells. 7806062 1995