Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE Serum chemerin, TGF-β, IL-6, and MCP-1 levels were significantly higher in T2DM groups than in NGR group, and BMI, WSR, fasting plasma glucose (FPG), 2hPG, glycated hemoglobin (HbA1c), triglycerides (TG), and HOMA-IR were higher in T2DM-V subgroups with moderate or severe lower extremity macroangiopathy than in NGR group, simple T2DM group, and T2DM-V subgroup with mild macroangiopathy. 31078135 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Although the gene variants were not significant in type 2 diabetes and insulin resistance groups, IRAK1, TLR4, and TIRAP gene variants were found to be associated with TNF-α, IL-6, MCP-1, and IL-1β levels. 31222667 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE We assessed interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1RA), monocyte chemoattractant protein-1 (MCP-1), and cortisol responses to acute stress in 135 people with Type 2 diabetes. 30693534 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Monocyte chemoattractant protein-1 (MCP-1) is an important inflammatory chemokine related to insulin resistance and type II diabetes. 30909920 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Association of urinary monocyte chemoattractant protein-1 (MCP-1) and kidney injury molecule-1 (KIM-1) with risk factors of diabetic kidney disease in type 2 diabetes patients. 31250339 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Using a high fat diet-fed T2D mice model this study further demonstrated that VK1 supplementation (1, 3, 5 μg per kg BW, 8 weeks) dose-dependently decreased the body weight gain, glucose intolerance, fasting glucose, glycated hemoglobin, HOMA-IR, and cytokine secretion (MCP-1 and IL-6) in T2D mice. 29227493 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE In patients with T2D, reductions in depressive symptoms were associated with reductions in high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-18 and IL-1 receptor antagonist (IL-1RA) (P ≤ 0.016), whereas no associations were seen for IL-6, CCL2 and adiponectin. 29525039 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE The levels of MCP-1 and SFRP5 were decreased while visfatin and RBP4 levels were increased in patients with T2DM compared to those in the control individuals (<i>P </i>< 0.01). 29785210 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE Antagonism of MCP-1, a chemokine pivotally expressed in T2D BM-ADs, prevented the T2D BM-AD secretome from converting BM-MSCs into ADs. 29703845 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 GeneticVariation disease BEFREE The purpose of the present study was to investigate distribution of monocyte chemoattractant protein-1 (MCP-1) -2518A/G and vascular endothelial growth factor (VEGF) -634G/C polymorphisms in type 2 diabetes melitus patients (T2DM) presenting diabetic foot ulcer (DFU). 29901584 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE Results showed that VK1 supplementation [1, 3, 5 μg/kg body weight (BW), 8 weeks] dose dependently improved the glucose tolerance; decreased BW gain, fasting glucose and insulin, glycated hemoglobin, HOMA-IR and cytokine secretion (monocyte chemoattractant protein-1 and interleukin-6); and regulated the signaling pathway of hepatic glucose metabolism [sirtuin 1 (SIRT1)/AMP-activated protein kinase (AMPK)/phosphoinositide 3-kinase/phosphatase and tensin homolog/glucose transporter 2/glucokinase/glucose 6 phosphatase], lipid oxidation (peroxisome proliferator-activated receptor alpha/carnitine palmitoyltransferase 1A) and inflammation (nuclear factor kappa B) in T2D mice. 29175667 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. 29017158 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE In this study, we investigated the serum levels of monocyte chemotactic protein 1 (MCP-1) and cathepsin-D in patients with T2DM-Y without and with diabetic retinopathy. 28336215 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Molecular mechanism studies demonstrated an impaired signaling cascade, IRS1/PI3K/Akt/AMPK/GLUT4/GSK3β, of glucose metabolism in the skeletal muscle and increase in serum levels of pro-inflammatory cytokines, CRP and MCP1 in T2D rats. 28802226 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE We suggest that MCP-1 might be a molecular marker of type 2 diabetes. 28266270 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE Lower ADIPOQ and higher TNF and MCP1 mRNA expression in visceral adipose tissue may be correlated with obesity and T2DM in the Uygur population. 27573980 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE In comparison to monocyte chemoattractant protein-1 (MCP-1; also known as CCL2), the chemokines MCP-2 (CCL8) and MCP-3 (CCL7) are partial agonists of their shared receptor CCR2, a key regulator of the trafficking of monocytes and macrophages that contribute to the pathology of atherosclerosis, obesity, and type 2 diabetes. 28536301 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.300 GeneticVariation disease BEFREE A meta-analysis was performed to assess the MCP-1 polymorphism associated with DR susceptibility in type 2 diabetes mellitus. 27505625 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE The purpose of this study is to investigate the role of MCP-1 in the pathogenesis of diabetic retinopathy (DR) in Han Chinese patients with Type 2 diabetes. 25981750 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE Among the proinflammatory mediators, the mRNA expression of MCP-1, IL1-β, NFκB, TLR2, and TLR4 were also significantly (<i>p</i> < 0.05) increased in T2DM. 27904654 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.300 GeneticVariation disease BEFREE Association between new onset diabetic retinopathy and monocyte chemoattractant protein-1 (MCP-1) polymorphism in Japanese type 2 diabetes. 25913234 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.300 GeneticVariation disease BEFREE MCP-1 -2518 GG genotype and G allele may increase the risk of progression to ESRD in T2D cases. 25154422 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Therapeutic disease RGD Lipid metabolism and inflammation modulated by Vitamin D in liver of diabetic rats. 25899686 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.300 GeneticVariation disease BEFREE The MCP-1 Gene A-2518G Polymorphism Confers an Increased Risk of Vascular Complications in Type 2 Diabetes Mellitus Patients. 26083329 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.300 GeneticVariation disease BEFREE MCP-1 -2518G/A gene polymorphism was not associated with nephropathy risk in T2DM among Chinese, Koreans, and Turks. 24059294 2014