|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
|
30838396 |
2019 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-22 and CCL2 secretion by eESCs stimulated by NK cells contributes to the induction of macrophage recruitment and is thus implicated in the development of endometriosis.
|
31295376 |
2019 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the effect of pre-operative oral simvastatin administration on MCP-1 gene expression and serum MCP-1 protein levels in patients with endometriosis.
|
28950844 |
2017 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concentrations of SCGF-β, IL-8, HGF, and MCP-1 were significantly higher, while IL-13 was significantly lower in the endometriosis group compared with the group without endometriosis.
|
28433374 |
2017 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ESC from endometrial biopsies of six subjects with histologically confirmed endometriosis were treated for 6 h with medium alone or with TNF-α (10 or 100 ng/ml) in the presence of dienogest (DNG), medroxyprogesterone acetate (MPA) and norethisterone acetate (NETA) 10-5 M. The progestin-mediated change in IL6, IL8 and MCP-1 mRNA transcription was measured, as was the PRA, PRB, GR, AR and MCR protein expression.
|
28412861 |
2017 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of TFF3 in PF of women with endometriosis were significantly increased ( P < .05) and correlated with local levels of known biomarkers for endometriosis: cancer antigen (CA) 125, CA-19-9, interleukin 8, monocyte chemotactic protein 1, and matrix metalloproteinase 7.
|
27330011 |
2017 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest a reciprocal activation of macrophages and endometriotic cells via the soluble factors CCL2 and IL6, which may contribute to the development of endometriosis.
|
29036448 |
2017 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nonetheless, interferon (IFN)-γ, Interleukin (IL)-10 and monocyte chemoattractant protein-1 (MCP-1) levels were higher in the supernatant of E-MenSCs-PBMC co-cultures.
|
24939730 |
2014 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.
|
22267540 |
2012 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study has demonstrated for the first time that the abnormal lower CD82 expression in ESCs induced by TCDD and estrogen may be an important molecular basis of endometriosis pathogenesis through enhancing the CCL2 secretion and CCR2 expression and the invasion of ESCs via MAPK and integrinβ1 signal pathway.
|
21685244 |
2011 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, we observed that the sex steroid treatment stimulated MCP-1 mRNA and protein expression in HEECs from women with endometriosis (P < .05).
|
19933497 |
2010 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Proliferative phase samples showed higher epithelial IL-8 and MCP-1 expressions in eutopic endometrium of women with endometriosis compared with that of normal women.
|
18314120 |
2009 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Three cytokines were significantly higher in the serum of subjects with endometriosis than in the control group: interleukin-6 (IL-6) [4.41 pg/ml (range: 1.47-15.01) versus 0.97 pg/ml (range: 0.29-2.98), respectively; p<0.001], monocyte chemotactic protein-1 (MCP-1) [37.91 pg/ml (range: 24.54-94.74) versus 22.13 pg/ml (range: 13.85-39.45), respectively; p<0.001], and interferon-gamma (INF-gamma) [19.01 pg/ml (range: 1.19-73.52) versus 0.30 pg/ml (range: 0.00-13.05), respectively; p<0.001].
|
17582674 |
2008 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
During menstrual phase, increased endometrial mRNA levels of alpha(V) integrin, combined alpha(V)beta(3) integrins, and increased peritoneal IL-1 beta mRNA levels--but decreased peritoneal MCP-1 mRNA levels--were observed in women with endometriosis compared with control subjects.
|
17678915 |
2008 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Panel of markers can accurately predict endometriosis in a subset of patients.
|
17706208 |
2008 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In contrast, the percentages of CD14+ cells producing TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 were significantly higher in PB than PF of women with endometriosis.
|
17207568 |
2008 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This method showed a sensitivity of 92.2%, a specificity of 81.6%, a negative predictive value of 83.3%, a positive predictive value of 92.3%, a likelihood ratio of a positive test result of 5.017, and a likelihood ratio of a negative test result of 0.096 to predict the presence or absence of endometriosis.The results imply the potential use of CCR1 mRNA, MCP-1, and CA125 protein measurements for the diagnosis or exclusion of endometriosis.
|
19050323 |
2008 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesize that increased levels of CCL2 in the endometriotic environment may upregulate FASLG expression in human endometrial stromal cells and induce a local immunotolerance in endometriosis.
|
16687653 |
2006 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among various chemokines, regulated-on-activation, normal-T-cell-expressed and -secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) concentrations have been shown to be increased in the peritoneal fluid of women with endometriosis.
|
14981141 |
2004 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
ELISA was used to measure MCP-1 in the culture supernatants exposed to oxidized LDL and peritoneal fluid from control and endometriosis patients.
|
12372466 |
2002 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Peritoneal macrophages of women with endometriosis demonstrated an increased capacity to secrete MCP-1 either spontaneously or after stimulation with lipopolysaccharide.
|
12009356 |
2002 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serum of women with endometriosis induced higher secretion of MCP-1 by U937 cells than that of control women, particularly in the initial stages of endometriosis (stages I-II), and recombinant IL-1RII (rIL-1RII) significantly blocked that secretion.
|
12372465 |
2002 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MCP-1 may be involved in the histogenesis and early development of peritoneal endometriosis.
|
11213838 |
2001 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Effect of hormonal agents on monocyte chemotactic protein-1 expression by endometrial epithelial cells of women with endometriosis.
|
11056242 |
2000 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ovarian hormones modulate monocyte chemotactic protein-1 expression in endometrial cells of women with endometriosis.
|
10871649 |
2000 |