CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker group BEFREE The follicular phase of the menstrual cycle was associated with an elevated CCL2 level and retention of resident memory CD4+ T cells, which has implications for increased susceptibility to HIV infection. 30383238 2019
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker group BEFREE In this review, we focus on the distinctive and complementary contributions of CCR5 and CCR2/CCL2 in HIV infection, multiple sclerosis, liver fibrosis and associated hepatocellular carcinoma. 31377844 2019
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker group BEFREE Because sICAM1 and CCL2 are associated with an increased risk of HIV-associated neurocognitive disorder, we propose that an established Vpr-ELISA would be useful for monitoring the risk of HIV complications during latent HIV infection. 30938169 2019
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker group BEFREE GCF IL-8, G-CSF, as well as serum IL-8, MCP-1 and GM-CSF may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use. 28043030 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation group BEFREE Our findings suggest that mucosa-biased gradients of IP-10, macrophage inflammatory protein-1β, IL-8, and monocyte chemotactic protein-1 are associated with an increased risk of HIV infection. 28187085 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker group BEFREE Twelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γ inducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages from 58 HIV seroconverters and 58 matched uninfected controls and in plasma from a subset of 107 of these women from the Centre for the AIDS Programme of Research in South Africa 004 tenofovir gel trial. 25900168 2015
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation group BEFREE Host-pathogen interactions in the development of metabolic disturbances and atherosclerosis in HIV infection: the role of CCL2 genetic variants. 20573518 2010
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 GeneticVariation group LHGDN Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection. 16636247 2006
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 AlteredExpression group BEFREE There were also significant correlations indicating a close association between MCP-1 and HIV disease activity. 16445900 2006
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 AlteredExpression group BEFREE Similarly, the CCR2b ligands MCP-1 and MCP-3 inhibit productive infection of PBMCs by both CCR5- and CXCR4-dependent strains of HIV-1, suggesting that expression of the MCP-1 chemokine may affect HIV infection via signaling through the CCR2 receptor and subsequent desensitization of the CCR5 and/or CXCR4 signaling pathway. 10497106 1999
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 AlteredExpression group BEFREE In addition, because human immunodeficiency virus (HIV) infection in vivo and in vitro has been shown to dysregulate the production of and/or the response to cytokines, PBMCs from both healthy uninfected and HIV-infected individuals were studied for their constitutive and IL-6-induced expression of MCP-1. 9414293 1998
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.400 Biomarker group CTD_human