Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, correlations between urinary monocyte chemoattractant protein-1 and glycemic and inflammatory marker levels revealed the role of hyperglycemia and chronic inflammation in the pathogenesis of diabetic kidney disease.
|
31250339 |
2019 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The intervention also suppressed serum monocyte chemotactic protein-1 and interleukin-6 levels, which are proinflammatory cytokines involved in the development of insulin resistance and hyperglycemia.
|
30502681 |
2019 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<i>In vitro</i> experiments in rat macrophages showed that hyperglycemia treatment suppresses Nrf2 activation, resulting in oxidative stress with decreased expression of antioxidant genes, including NAD(P)H:quinone oxidoreductase 1 and heme oxygenase 1, together with increased secretion of proinflammatory cytokines, including interleukin 1β (IL1β), IL6, and monocyte chemoattractant protein-1.
|
31616304 |
2019 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Following hyperglycemia, retinal pigmented epithelial (RPE) cells, endothelial cells, and Müller's glial cells are of utmost importance for MCP-1 production, and vitreous MCP-1 levels rise in patients with DR.
|
30607767 |
2019 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hyperglycemia induces NF-κB activation and MCP-1 expression via downregulating GLP-1R expression in rat mesangial cells: inhibition by metformin.
|
31136032 |
2019 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched to fined interventional studies from the effects of chromium on inflammatory biomarkers such as tumour necrosis factor a (TNF-a), C-reactive protein (CRP), interleukins, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and adipocytokines in hyperglycaemia and diabetes.
|
31330062 |
2019 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Stress hyperglycemia and diabetes may contribute to high monocyte chemoattractant protein-1 levels and prolonged inflammation.
|
30988769 |
2019 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Canagliflozin attenuates the progression of atherosclerosis, reducing (1) hyperlipidemia and hyperglycemia, and (2) inflammatory process, by lowering the expression of inflammatory molecules such as MCP-1 and VCAM-1.
|
30049285 |
2018 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hyperglycemia increased the mRNA expression and protein levels of malondialdehyde (MDA), superoxide dismutase (SOD), monocyte chemoattractant protein‑1 (MCP‑1), intercellular adhesion molecule‑1 (ICAM‑1), fibronectin (FN), collagenase type 1 (COL‑1), HMGB1, RAGE and NF‑κB, and the effects could be reversed by dapagliflozin in a concentration‑dependent manner.
|
30132524 |
2018 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The rapid decrease of blood creatinine, urine creatinine, and blood urea nitrogen suggested that the recovery of renal functions compromised by hyperglycemia could also be attributed to MCP-1.
|
24600221 |
2014 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia induces MCP-1 production in vascular endothelial cells and retinal pigmented epithelial cells, and has been implicated as a causal factor in the facilitation of vascular complications in diabetes.
|
23549806 |
2013 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Experimental evidence indicates that previous hyperglycemia is associated with persistent expression of the NFκB p65 gene, which activates NFκB-dependent proteins, such as MCP-1, which are implicated in diabetes-associated vascular injury.
|
20599797 |
2010 |