CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease BEFREE Furthermore, TAS-115 inhibited the phosphorylation of c-FMS, a receptor of macrophage colony-stimulating factor, in murine bone marrow-derived macrophages and decreased the production of CCL2, another key molecule for inducing pulmonary fibrosis, under the stimulation of macrophage colony-stimulating factor. 30540913 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease BEFREE Some chemokines, such as CCL2 and CXCL4, have been identified as biomarkers of skin and lung fibrosis in SSc. 28730919 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease BEFREE Animal models have suggested that CCR2-dependent signalling contributes to the pathogenesis of pulmonary fibrosis, but global blockade of CCL2 failed to improve the clinical course of patients with lung fibrosis. 28780502 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease CTD_human Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. 26163174 2015
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease BEFREE The significantly increased binding of p65 and c-Jun to the CCL2 promoter was also observed in the lung tissue of bleomycin-induced pulmonary fibrosis murine model. 23583295 2013
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease BEFREE Targeting PAR(1) on the pulmonary epithelium may offer a unique opportunity for therapeutic intervention in pulmonary fibrosis and other inflammatory and fibroproliferative conditions associated with excessive local generation of thrombin and CCL2 release. 19060230 2009
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease CTD_human A significant negative correlation was observed between the percentage of Dlco and MCP-1 and MIP-1 alpha levels in BAL fluid in patients with PF (r=-0.65, p=0.003; r=-0.48, p=0.04; respectively). 17720292 2007
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease LHGDN M-CSF-/- and CCL2-/- mice had less lung fibrosis, mononuclear phagocyte recruitment, collagen deposition, and connective tissue growth factor (CTGF) expression after bleomycin administration than wild-type littermates. 17431224 2007
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease CTD_human Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. 16324872 2006
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 AlteredExpression disease BEFREE Elevated serum levels of MCP-1 and MIP-1alpha significantly correlated with the presence of pulmonary fibrosis. 10403930 1999
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.570 Biomarker disease RGD In this study, MCP-1 expression in lungs of rats with bleomycin (BLM)-induced pulmonary fibrosis is examined to evaluate its cellular origin and potential role in pathogenesis. 7525714 1994