CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE In the subsequent validation cohort analysis, we identified that the AUC of MCP-1 in diagnosing ATB and differentiating ATB from LTBI were 0.97 and 0.89, respectively, which was generally consistent with the results of the discovery cohort. 30528869 2019
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE In addition, nominal significance was observed for an association between TB incidence and both the eight paired genotypes in the overall patient cohort (0.017 < p < 0.05) and the CCL2 -2518A/G polymorphism among males (dominant model, OR = 0.55, p = 0.041; log-additive model, OR = 0.57, p = 0.018). 29608337 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression disease BEFREE Higher mRNA expression levels of inducible nitric oxide synthase, C-C motif chemokine ligand 2 and IL-12 were observed in macrophages from all in-contact cattle than in macrophages from their TB-infected counterparts, which expressed more tumour necrosis factor-α; however, the differences were not statistically significant owing to individual variation. 27833091 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE Human alveolar macrophages produced CCL2 in a PGL-dependent fashion following infection, arguing for the potential of PGL-blocking interventions or PGL-targeting vaccine strategies in the prevention of tuberculosis.VIDEO ABSTRACT. 28844797 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE In conclusion, these results indicate a specific role for both p38 MAPK and IL-4 in ESAT-6-induced MCP-1 production by macrophages and suggest a pathway with significance in tuberculosis pathogenesis. 27154637 2016
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE In addition, the DEGs, such as CD14 molecule (CD14) and chemokine (C-C motif) ligand 2 (CCL2), were enriched mostly in the pathways related to tuberculosis, phagosome and NF-kappa B signaling pathway. 26503224 2016
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression disease BEFREE Persons with the GG genotype produced significantly lower CCL2 levels in response to M. tuberculosis antigen stimulation (AA+AG vs. GG, P = 0.038). 27510253 2016
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE Genetic association meta-analysis: a new classification to assess ethnicity using the association of MCP-1 -2518 polymorphism and tuberculosis susceptibility as a model. 26518714 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE Subset analyses identified CCL2 as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72-0.88]). 26524966 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE The results revealed an association between the MCP-1 -2518A/G polymorphism and human TB susceptibility under a recessive model (GG vs GA+AA), dominant model (GG+GA vs AA), and homozygote comparison (GG vs AA) model for the entire database. 26125747 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE To explore the role of the MCP-1 gene in the susceptibility to PTB in a North Chinese population, we evaluated the association between MCP-1 -2518A/G gene polymorphisms and the risk for tuberculosis. 25966175 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE To investigate the relationship between -2518A/G and -362G/C polymorphisms in MCP-1 gene and the susceptibility of tuberculosis, a systematic literature search for relevant articles published up to January, 2013 was conducted in the databases of PubMed, Elsevier, Web of Science, Wanfang and CNKI. 23933403 2013
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE The CCL2-2518G allele (OR 1.51, 95%CI 1.11-2.04, P = 0.008) showed significant association with susceptibility to TB. 22137597 2012
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression disease BEFREE Peripheral blood mononuclear cells obtained from 21 pulmonary tuberculosis (PTB) patients and 24 healthy controls (HCs) were cultured for 48 h with culture filtrate antigen (CFA) of Mycobacterium tuberculosis with or without vitamin D(3) at a concentration 1 × 10(-7)M. The relative mRNA expression of monocyte chemoattractant protein-1 (MCP-1, CCL2), macrophage inflammatory protein-1α (MIP-1α, CCL3), macrophage inflammatory protein-1β (MIP-1β, CCL4), and regulated upon-activation, normal T cell-expressed and secreted (RANTES, CCL5) and IFN-γ inducible protein-10 (IP-10, CXCL10) chemokines were estimated from 48 h old macrophages using real-time polymerase chain reaction (RT-PCR). 22800603 2012
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE The monocyte chemotactic protein-1 (MCP-1) is a chemokine that plays an important role in the recruitment of monocytes to M. tuberculosis infection sites, and previous studies have reported that genetic variants in MCP1 are associated with differential susceptibility to pulmonary tuberculosis (PTB). 22384203 2012
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE This meta-analysis suggested that the -2518A/G polymorphism of MCP-1 gene would be a risk factor for TB in Asians and Latinos, while not in Africans. 22859936 2012
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE In a Ghanaian tuberculosis (TB) case-control study group, associations of the MCP1 -362C and the MCP1 -2581G alleles with resistance to TB were recently described. 21504590 2011
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE Genomic DNA from patients with active TB (168 cases of pulmonary TB and 55 cases of extrapulmonary TB) and ethnically controls (150 cases) was genotyped for the MCP-1 -2518 A/G SNP by polymerase chain reaction fragment length polymorphism (PCR-RFLP). 21384169 2011
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression disease BEFREE We have therefore carried out a detailed analysis of CCL-2 genotype SNP -2518 (A/G transition) with plasma CCL-2 levels and related these levels to tuberculin skin test positivity in asymptomatic community controls with no known exposure to tuberculosis and in recently exposed household contacts of pulmonary tuberculosis patients. 21991356 2011
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE The present study found an association of the CCL2 tag SNP rs4586 C allele and pediatric TB disease in males, suggesting that gender may affect the susceptibility to TB even in children. 21556333 2011
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression disease BEFREE Carriers of these susceptibility genotypes might be at increased risk of developing TB because they produce high levels of MCP-1, which enhances the induction of MMP-1 production by M. tuberculosis-sonicate antigens to higher levels than in carriers of the other two-locus MCP-1 MMP-1 genotypes studied. 20111728 2010
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE MCP-1 -362C was associated with resistance to TB in the case-control collection (OR 0.83, P(corr) = 0.00017) and in the affected families (OR 0.7, P(corr) = 0.004). 18940815 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation disease BEFREE CCR2 V64I (G/A), monocyte chemoattractant protein-1 (MCP-1) -2518 A/G, stromal cell derived factor-1alpha; (SDF-1alpha) 3'UTR G/A and DC-SIGN gene polymorphisms were studied by polymerase chain reaction based methods in HIV-1 infected patients without TB (n=151), with pulmonary TB (PTB) (n=81) and extrapulmonary TB (n=31), 155 PTB patients without HIV and 206 healthy controls. 19942750 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE CCL2 secretion in response to M. tuberculosis was significantly greater than to BCG in the PTB and D-ETB groups. 20041183 2009
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker disease BEFREE Given the roles played by IFN-gamma and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dené. 18713057 2008