|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
MCP-1 levels in the WT sepsis group and the KO sepsis group at 24 hours postoperatively were significantly higher than those at 6 hours postoperatively (P < .05).
|
31701658 |
2020 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Stratification of the interventional cohort by mesenchymal stem/stromal cell dose further revealed patient-specific and dose-dependent perturbations in cytokines, including an early but transient dampening of pro-inflammatory cytokines (e.g., interleukin-1β, interleukin-2, interleukin-6, interleukin-8, and monocyte chemoattractant protein 1), suggesting that mesenchymal stem/stromal cell treatment may alter innate immune responses and underlying sepsis biology.
|
30720538 |
2019 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Sepsis was associated with high levels of IL-6, IL-10, G-CSF, and MCP1 and low levels of IFNγ, early sepsis with high levels of IL-6 and G-CSF, severe sepsis with high levels of IL-6 and IL-10, while deaths or sequelae was associated with low levels of IL-4, IL-12, IFNγ, and high levels of GM-CSF.
|
29562764 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The findings suggest that PTX3, MCP1 and Ang2 maybe early predictors to evaluate the severity of sepsis and septic shock with the latest Sepsis 3.0 definitions.
|
31489646 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-38 administration decreased the inflammatory response, as reflected by lower levels of cytokines and chemokines (including IL-6, TNF-α, interleukin 10, interleukin 17, interleukin 27, CXCL1, and CCL2), and less damage to tissues (including lung, liver, and kidney) in CLP-induced sepsis.
|
29762676 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Patients who developed sepsis (n = 33) had higher interleukin (IL)-6, IL-18, and monocyte chemotactic protein-1 (MCP-1) concentrations at admission than patients (n = 27) who did not develop sepsis.
|
29465571 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Both MCP-1 and IL-6 revealed prognostic value for short- and mid-term all-cause mortality in patients with sepsis and septic shock according to latest sepsis-3 definitions.
|
28834779 |
2018 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Tg mice had a reduced inflammatory response during sepsis, with decreased macrophage and neutrophil infiltration into tissues, which was associated with reduced expression of monocyte chemotactic protein-1 and macrophage inflammatory protein-2.
|
29975792 |
2018 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.
|
29769838 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
A Cox proportional hazards model focussed on the acute phase showed that the above combined score was significantly related with patient prognosis, suggesting that the cytokine network of IL-6, IL-8, MCP-1 and IL-10 could play a pivotal role in the acute phase of sepsis.
|
30228372 |
2018 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The addition of the early MCP-1 levels to the ISS significantly improves its ability to predict development of sepsis.
|
29620667 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Previous studies have indicated that monocyte chemoattractant protein-1 (MCP‑1), also referred to as C‑C motif chemokine ligand 2, has a significant role in the pathogenesis of sepsis, however, how microRNAs (miRs) contribute to this process remains to be fully elucidated.
|
29568906 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We finally found monocyte chemoattractant protein 1 (MCP-1) as the most useful biomarker to distinguish the two sepsis groups; namely, non-surviving patients (n = 56) exhibited significantly higher plasma concentrations of MCP-1 compared to survivors (n = 87).
|
28202856 |
2017 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We conclude that MCP-1/CCL2 plays a significant role in the pathogenesis of sepsis, which has potentially important therapeutic implications.
|
28472164 |
2017 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
PD-L1 gene deficiency reduced ileal permeability, tissue levels of IL-6, TNF-α and MCP-1, and prevented ileal tight junction protein loss compared to WT after sepsis.
|
27782294 |
2017 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Elevated levels of interleukin 8 (IL-8), IL-6, IL-10, monocyte chemotactic protein 1, and CRP were associated with reduced time to posttraumatic sepsis in Cox regression analysis.
|
26496101 |
2015 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
RGD |
The role of redox status on chemokine expression in acute pancreatitis.
|
19111613 |
2009 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Secretion of the CC chemokine, MCP-1 (CCL2) by LPS-activated endothelial cells contributes substantially to the pathogenesis of sepsis.
|
18954908 |
2009 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our objective was to investigate the levels of chemokines (MIP1-alpha, MCP-1, and Gro-alpha), Interleukin-18 (IL-18), and Interleukin (IL-6) in bronchoalveolar lavage (BAL) fluid and serum at the onset and ongoing states of sepsis as defined by the American College of Chest Physicians/Society of Critical Care Medicine in septic surgical ICU patients.
|
11236899 |
2001 |