CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.080 Biomarker disease BEFREE We studied single-nucleotide polymorphisms (SNPs) in genes encoding three CCR5 ligands (CCL3 (MIP-1a), CCL4 (MIP-1b)and CCL5 (RANTES)) along with an adjacent gene encoding a CCR2ligand (CCL2 (MCP-1)) to identify candidate markers for HIV-1 infection and pathogenesis. 21975429 2012
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.080 Biomarker disease BEFREE We show that the chemokine (c-c Motif) Ligand-2 (CCL2) increases PrP(C) release from CNS cells, while HIV-1 infection alters PrP(C) release from peripheral blood mononuclear cells. 20724601 2010
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.080 Biomarker disease BEFREE Effect of genetic variants of CCR2 and CCL2 on the natural history of HIV-1 infection: CCL2-2518GG is overrepresented in a cohort of Spanish HIV-1-infected subjects. 17091019 2007
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.080 AlteredExpression disease BEFREE These findings indicate that prednisolone suppresses both HIV-1 viral load and CCL2 mRNA expression, an association which might be exploited for future anti-inflammatory therapeutic strategies in HIV-1 infection. 17707134 2007
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.080 Biomarker disease BEFREE Inhibition of increased CCL2 production could provide a new therapeutic intervention in HIV-1 infection. 16916890 2006
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.080 Biomarker disease BEFREE Our findings suggest that MCP-1 antagonists may be useful in HIV-1 infection, especially for HAD, and that HIV+ individuals possessing the MCP-1 -2578G allele may benefit from early initiation of antiretroviral drugs that effectively cross the blood-brain barrier. 12374865 2002
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.080 AlteredExpression disease BEFREE We found an increased mRNA expression of monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and RANTES by macrophages after HIV-1 infection. 11031691 2000
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.080 AlteredExpression disease BEFREE In vitro, productive HIV-1 infection of monocyte-derived macrophages upregulated the secretion of MCP-1. 9708412 1998