Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE This review focuses on findings which collectively add new insights on how Nef-induced CCL2 expression contributes to neurotropism and neurovirulence of HIV and SIV and elucidates why adjuvant targeting of CCL2 could be a therapeutic option for HIV-infected persons. 31681324 2019
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation disease BEFREE Median proportion of PBMCs that were activated monocytes (16.6 vs. 5.3), and median CSF CXCL10 (10658 vs. 2530 units), CCL2 (519 vs. 337 units) and HIV RNA (727 vs. 50 c/mL) were higher in neurosyphilis than in uncomplicated syphilis (P ≤ .001 for all comparisons). 28525592 2017
Human immunodeficiency virus (HIV) II infection category B1
0.100 AlteredExpression disease BEFREE Among HIV-infected participants, aspartame intake was significantly associated with coronary plaque (<i>P</i> = .002) and noncalcified plaque (<i>P</i> = .007) segments, as well as markers of inflammation/immune activation (monocyte chemoattractant protein 1 and lipoprotein-associated phospholipase A<sub>2</sub>), which may contribute to increased atherogenesis. 28695142 2017
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation disease BEFREE The findings support the role of immunologically related genetic differences in CCL2 and CCL3 in neurocognitive functioning among HIV+ individuals; however, their impact is minor. 24737013 2014
Human immunodeficiency virus (HIV) II infection category B1
0.100 AlteredExpression disease BEFREE Consistent with this hypothesis, adolescent HIV-1 tg rats demonstrated a depressive-like behavioral phenotype, had decreased levels of cell proliferation, and exhibited elevated expression of monocyte chemotactic protein-1 (Mcp-1) in the hippocampus relative to controls. 25271421 2014
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Gene array analysis revealed an impressive increase in the transcription of the gene for the CCL2/MCP-1 chemokine in astroglial cells isolated from HIV-1-infected co-cultures compared with cells from uninfected co-cultures. 20737475 2010
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation disease BEFREE The objective of the study was to assess the feasibility of measuring human immunodeficiency virus 1 (HIV-1) proviral deoxyribonucleic acid (DNA) and associated single-nucleotide polymorphism (SNP) of monocyte chemoattractant protein 1 (MCP1) in pediatric cerebrospinal fluid (CSF). 17169271 2006
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE To further investigate the correlation between CCL2 and HIV/SIV CNS disease, the authors sequenced the CCL2 promoter of 29 pigtailed macaques examined in their accelerated and consistent SIV model in which all infected macaques develop AIDS but only 69% developed moderate/severe CNS lesions. 17162657 2006
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Increased brain levels of monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, are found in patients with human immunodeficiency virus type 1 (HIV-1)-associated dementia and other acute and chronic neurologic diseases. 16206198 2006
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Increased central nervous system (CNS) levels of monocyte chemoattractant protein 1 [CC chemokine ligand 2 (CCL2) in the systematic nomenclature] have been reported in chronic neurological diseases such as human immunodeficiency virus type 1-associated dementia, amyotrophic lateral sclerosis, and multiple sclerosis. 15857890 2005
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. 11574916 2001
Human immunodeficiency virus (HIV) II infection category B1
0.100 AlteredExpression disease BEFREE It has been shown that the human immunodeficiency virus type 1 (HIV-1) Tat protein can specifically enhance expression and release of monocyte chemoattractant protein 1 (MCP-1) from human astrocytes. 10644332 2000