Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The identification of constitutive eotaxin mRNA expression in multiple tissues suggests that in addition to regulating airway eosinophilia, eotaxin is likely to be involved in eosinophil recruitment into other tissues as well as in baseline tissue homing.
|
7869037 |
1995 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These results now provide a mechanism involving eotaxin to explain the eosinophil infiltration seen in a variety of human disease; as such, an eotaxin antagonist may be a novel therapy for certain human diseases characterized by tissue eosinophilia.
|
8597956 |
1996 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
This data suggests that the development of tissue eosinophilia in vivo involves a two-step mechanism elicited by interleukin 5 and eotaxin.
|
8784786 |
1996 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicate a contributory role for eotaxin in the generation of peripheral blood and antigen-induced tissue eosinophilia.
|
9034156 |
1997 |
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Levels of eotaxin expression correlated directly with the extent of tissue eosinophilia.
|
10194423 |
1999 |
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Airway eosinophilia is a prominent feature of asthma that is believed to be mediated in part through the expression of specific chemokines such as eotaxin, a potent eosinophil chemoattractant that is highly expressed by epithelial cells and inflammatory cells in asthmatic airways.
|
10351942 |
1999 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
There is increasing evidence that eotaxin is a key mediator in the development of tissue eosinophilia.
|
10691892 |
2000 |
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this review, we discuss the patterns of expression of IP-10, Mig, RANTES, MIP1-alpha, and eotaxin in HD and its subtypes, and the relationship to EBV positivity, LMP1 expression, tissue eosinophilia and T cell infiltration.
|
10830743 |
2000 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Eotaxin production by macrophages, eosinophils, and epithelial cells may play a more pronounced role in airway eosinophilia in nonatopic than in atopic asthma.
|
11097314 |
2000 |
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Regulation of IL-5 and eotaxin levels within the lung by IL-4 and IL-13 allows Th2 cells to elegantly co-ordinate tissue and peripheral eosinophilia.
|
11292021 |
2001 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
By using mice deficient in both IL-5 and eotaxin (IL-5/eotaxin(-/-)) we have abolished tissue eosinophilia and the induction of AHR in the allergic lung.
|
12045241 |
2002 |
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, intranasal administration of IL-25-expressing adenovirus or IL-25 protein resulted in the production of IL-4, IL-5, IL-13, and eotaxin mRNA in the lung and marked eosinophilia in the bronchoalveolar lavage and lung tissue.
|
12077275 |
2002 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
The predominant cell type inhabiting NPs is the eosinophil, and the chemokine eotaxin is believed to play an important role in NP eosinophilia.
|
12916705 |
2003 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
There is growing evidence that eotaxin is a key mediator in the development of tissue eosinophilia.
|
15144475 |
2004 |
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AAV2/9 sh47 virus significantly reduced airway hyperresponsiveness, airway resistance, CCL11 levels, and eosinophilia in the lungs of sensitized mice.
|
22913580 |
2012 |
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Levels of eotaxin-1 in the colon were correlated with eosinophilia only in tissues from active Crohn's disease patients.
|
26874691 |
2016 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, rIL-35 dramatically reduced LPS-induced airway eosinophilia in EBI3-deficient mice, with concomitant reduction of CCL11 and CCL24, whereas neutralization of IL-35 significantly increased airway eosinophils in LPS-treated wild-type mice.
|
27881708 |
2017 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Ten milligram per kilogram (total anthocyanins) of a commercially available, anthocyanin-rich New Zealand "Ben Ard" blackcurrant extract ("Currantex 30") attenuated ovalbumin-induced inflammation, eosinophilia (by 52.45 ± 38.50%), and CCL11 production (by 48.55 ± 28.56%) in a mouse model of acute allergic lung inflammation.
|
28393456 |
2017 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-37 inhibits IL-4/IL-13-induced CCL11 production and lung eosinophilia in murine allergic asthma.
|
29319845 |
2018 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Before and after treatment, the eosinophilic biomarkers in nasal lavage were analyzed: nasal eosinophilia (number of eosinophils per high power field), eotaxin-1 and eotaxin-2.
|
30478909 |
2019 |
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Our identification of a correlation of spinous keratinocyte eotaxin staining with tissue eosinophilia may provide insight into local eosinophil chemotaxis.
|
31350578 |
2019 |