CCL20, C-C motif chemokine ligand 20, 6364

N. diseases: 242; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 Biomarker disease BEFREE Effects of Notch signalling on the expression of SEMA3C, HMGA2, CXCL14, CXCR7, and CCL20 in breast cancer. 30930637 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 Biomarker disease BEFREE Our results suggest that CCL20 can be a novel predictive marker for taxane response, and the blockade of CCL20 or its downstream pathway might reverse the taxane resistance in breast cancer patients. 30052635 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 Biomarker disease BEFREE Our results suggest that CCL20 can be a novel predictive marker for taxane response, and the blockade of CCL20 or its downstream pathway might reverse the taxane resistance in breast cancer patients. 30052635 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 Biomarker disease BEFREE Moreover, CCL20 elevated the receptor activator of nuclear factors kappa-B ligand/osteoprotegerin ratio in breast cancer and osteoblastic cells and mediated the crosstalk between these cells. 28851919 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 Biomarker disease BEFREE Moreover, CCL20 elevated the receptor activator of nuclear factors kappa-B ligand/osteoprotegerin ratio in breast cancer and osteoblastic cells and mediated the crosstalk between these cells. 28851919 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 GeneticVariation disease BEFREE Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). 24937182 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 GeneticVariation disease BEFREE Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). 24937182 2014
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 Biomarker disease BEFREE Since the microenvironment of breast cancer includes CCL20 chemokine, the purpose of this study was to determine whether CCL20 modulates the physiology of healthy breast epithelial cells in areas adjacent to the tumor. 23460117 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 Biomarker disease BEFREE Since the microenvironment of breast cancer includes CCL20 chemokine, the purpose of this study was to determine whether CCL20 modulates the physiology of healthy breast epithelial cells in areas adjacent to the tumor. 23460117 2013
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.350 Biomarker disease CTD_human ERE-independent ERalpha target genes differentially expressed in human breast tumors. 16298037 2005
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.350 Biomarker disease CTD_human ERE-independent ERalpha target genes differentially expressed in human breast tumors. 16298037 2005
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.320 Biomarker disease CTD_human Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes. 30603057 2018
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.320 Biomarker disease BEFREE Role of CCL20 mediated immune cell recruitment in NF-κB mediated TRAIL resistance of pancreatic cancer. 28188806 2017
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.320 AlteredExpression disease BEFREE CCL20/CCR6 expression profile in pancreatic cancer. 20459729 2010
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.310 Biomarker group BEFREE These results reveal a role for CCL20 also in tumor breast cell and point to CCL20 as a novel therapeutic target in cancer. 28618084 2017
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders
0.310 Biomarker group BEFREE The expression of various DC markers, MIP-3α, and E-cadherin in the tissue samples obtained from patients with warts, HPV-Bowen and HPV-unrelated skin diseases was evaluated by immunohistochemistry. 21715145 2011
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders
0.310 Biomarker group CTD_human Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. 16835338 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.310 Biomarker group CTD_human ERE-independent ERalpha target genes differentially expressed in human breast tumors. 16298037 2005
CUI: C0019207
Disease: Hepatoma, Morris
Hepatoma, Morris
0.300 Biomarker disease CTD_human Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes. 30603057 2018
CUI: C0019208
Disease: Hepatoma, Novikoff
Hepatoma, Novikoff
0.300 Biomarker disease CTD_human Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes. 30603057 2018
CUI: C0023904
Disease: Liver Neoplasms, Experimental
Liver Neoplasms, Experimental
0.300 Biomarker phenotype CTD_human Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes. 30603057 2018
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.300 Biomarker disease CTD_human Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes. 30603057 2018
CUI: C0086404
Disease: Experimental Hepatoma
Experimental Hepatoma
0.300 Biomarker disease CTD_human Pancreatic carcinoma cells colonizing the liver modulate the expression of their extracellular matrix genes. 30603057 2018
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction
0.300 Biomarker phenotype CTD_human The antihelmenthic phosphate niclosamide impedes renal fibrosis by inhibiting homeodomain-interacting protein kinase 2 expression. 28318631 2017
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes
0.300 Therapeutic disease CTD_human Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 21340626 2011