Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed at investigating the functions of endothelial progenitor cells (EPCs) in the pathophysiology of coronary artery spasm (CAS) and coronary artery disease (CAD), as well as to evaluate the correlation of these diseases with the number and function of EPCs, the plasma concentration of vascular endothelial growth factor 165 (VEGF165) and stromal cell-derived factor 1 (SDF-1).
|
29771429 |
2018 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The study found that CXCL12 and CNNM2 gene affects the risk of coronary heart disease, but the relationship with hypertension is unclear.
|
30180964 |
2018 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The study identified CSF1 and CXCL12 as causal mediators of CAD in humans.
|
30012324 |
2018 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We provide first clinical evidence that high platelet expression levels of SDF-1 influence clinical outcomes in CAD patients in a negative way.
|
27463607 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies identified the association of the <i>CXCL12</i> genetic locus (which encodes the chemokine CXCL12, also known as stromal cell-derived factor 1) with coronary artery disease and myocardial infarction (MI).
|
28154007 |
2017 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serum CXCL10 and CXCL12 chemokine levels are associated with the severity of coronary artery disease and coronary artery occlusion.
|
28189264 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study explores the platelet lipidome in symptomatic coronary artery disease (CAD) patients and the functional consequences of the chemokine CXCL12 and its receptors CXCR-4/-7 on lipid uptake in platelets.
|
28431006 |
2017 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Distinct SDF1 polymorphisms are associated with improved cardiovascular prognosis in CAD patients.
|
27607427 |
2016 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis.
|
26133117 |
2015 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results generate the hypothesis that the CXCL12 variant appears to influence coronary artery disease risk through arterial remodeling and thickening, whereas the WDR12 risk variant could be related to higher plaque vulnerability.
|
25804320 |
2015 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the stromal cell-derived factor 1 gene is associated with coronary heart disease in Chinese patients.
|
24950177 |
2014 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the function of SDF-1 rs1801157G/A polymorphism in various immune cells and examined its association with susceptibility to coronary artery disease (CAD).
|
24361877 |
2014 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because previous genome-wide association studies demonstrated an association between CXCL12 rs501120 and coronary artery disease, in the present study we assessed the potential association of this polymorphism with the risk of cardiovascular (CV) disease in 1,321 Spanish patients with RA.
|
22386691 |
2012 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Coronary artery disease risk alleles downstream of CXCL12 are associated with plasma protein levels of CXCL12 and appear to be related to CXCL12 transcript levels in two human cell lines.
|
21415067 |
2011 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This approach replicated HNRNPA3P1-CXCL12 association with CAD and identified new significant associations of CDKAL1, ST6GAL1, and PTPRD with CAD.
|
22216278 |
2011 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
CXCL12: a new player in coronary disease identified through human genetics.
|
22137643 |
2010 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data indicate that defects in SDF-1-triggered EPC-adhesion contribute to the functional impairment of EPCs in CAD, and that ERK-2 represents a new therapeutic target for functional improvement of EPC adhesion in CAD.
|
19363666 |
2009 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the effect of 5 common variations of chemokine and chemokine receptor genes (SDF1-3'A, CCR5-delta32, CCR2-64I, CX3CR1-V249I and CX3CR1-T280M) on predisposition to CAD.
|
16480760 |
2007 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the role of these polymorphisms together with the chemokine SDF-1-801A and the chemokine receptors CCR2-64I and CCR5Delta32 mutations in 318 patients with coronary artery disease (CAD) referred to coronary bypass surgery, comparing them with 320 healthy controls.
|
11500196 |
2001 |