|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
The systemic administration of bifunctional SDF-1-AnxA5 effectively provides cardioprotection after myocardial infarction.
|
31468674 |
2019 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Vildagliptin treatment induced active SDF-1, which preserved the cardiac SDF-1-CXCR4 homing axis for MI injury.
|
31495390 |
2019 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of Exo-SDF1 on cardiac function in MI mice were investigated in vivo.
|
30720220 |
2019 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR and confocal microscopy revealed that epicardial EPO treatment enhanced levels of intracardiac regenerative key indicators (SDF-1, CXCR4, CD34, Bcl-2, cyclin D1, Cdc2 and MMP2), induced transforming growth factor β (TGF-β)/WNT signaling in intramyocardial MSC niches through the direct activation of AKT and upregulation of upstream signals FOS and Fzd7, and augmented intracardiac mesenchymal proliferation 24 h after MI.
|
29752300 |
2018 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
SDF-1 has been shown in pre-clinical animal studies to improve heart function and survival after myocardial infarction, and to promote arteriogenesis, the growth of natural bypasses, compensating for the function of an occluded artery.
|
30360455 |
2018 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
CXCR4 strongly binds to CXCL12 and the resulting CXCLl2/CXCR4 axis is the molecular basis of their various biological functions, which include: (1) mediating immune and inflammatory response; (2) regulation of hematopoietic stem cell migration and homing; (3) an essential co-receptor for HIV entry into host cells; (4) participation in the process of embryonic development; (5) malignant tumor invasion and metastasis; (6) myocardial infarction, ischemic stroke and acute kidney injury.
|
29500940 |
2018 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together, the current findings suggest that the SDF1-rs1801157A/G gene variant may play an important role in relation to MI in this Iranian population.
|
28650670 |
2017 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Non-oxidizable HMGB1 induces cardiac fibroblasts migration via CXCR4 in a CXCL12-independent manner and worsens tissue remodeling after myocardial infarction.
|
28716707 |
2017 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Platelet surface expression levels of stromal cell derived factor 1 (SDF-1) are elevated in acute coronary syndrome and associated with LVEF% improvement after myocardial infarction (MI).
|
27463607 |
2017 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Unlike CXCR4, the classic receptor for CXCL12, the function of CXCR7 (the most recently identified receptor) in vascular responses to injury and in MI remains unclear.
|
28154007 |
2017 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
To verify the therapeutic activity of bone marrow mononuclear cells (BM-MNCs) selected by in vitro migration towards the chemokine stromal cell-derived factor-1 (SDF-1) in a mouse model of myocardial infarction (MI), we used BM-MNCs from patients with previous large MI recruited in the TransACT-1&2 cell therapy trials.
|
25889213 |
2015 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
200 patients (181 men age 57.3 ± 7.7 years) and 230 healthy controls (96 men, age 52 ± 11.9 years) were recruited to investigate the association between MI and SDF1-3'A polymorphism.
|
24751515 |
2014 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man.
|
21910857 |
2011 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.
|
21211798 |
2011 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction.
|
20016947 |
2010 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
SDF-1 alpha could improve cardiac structure and function after Myocardial infarction through angiogenic and anti-fibrotic actions.
|
19653123 |
2010 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, investigators have focused on the use of a chemokine, CXCL12, the only identified ligand for CXCR4, as a new therapeutic modality to recruit stem cells to individuals suffering from MI.
|
20133817 |
2010 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study showed a significant association between the SDF1-3'A polymorphism and MI in Chinese Han population.
|
19821058 |
2010 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
RGD |
The rats in the intervention groups were injected with SDF-1, anti-SDF-1 antibody or saline 4 days after myocardial infarction.
|
19187644 |
2009 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
On day 7 after myocardial infarction, marked expression of SDF-1alpha, and the number of CD133(+) cells was the highest in the AdV-SDF-1 injection hearts.
|
18577527 |
2008 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In a dog model of MI, We also examined and compared the differentially expressed pattern of SDF-1 between infarct area and border zone of myocardium in order to explore the implication of differentially distribution of SDF-1 in the mobilization and homing of stem cells to the damaged heart.
|
17910919 |
2007 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, M-CSF reduced infarct area and improved LV remodeling after MI through the recruitment of CXCR4(+) cells into the infarct myocardium by the SDF-1-CXCR4 axis activation; this suggests that the SDF-1-CXCR4 axis is as a potential target for the treatment of MI.
|
17640962 |
2007 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
These cells are mobilized into the peripheral blood after myocardial infarction and chemoattracted to the infarcted myocardium in an SDF-1-CXCR4-, HGF-c-Met-, and LIF-LIF-R-dependent manner.
|
15550692 |
2004 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction.
|
15533859 |
2004 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
RGD |
In order to study SDF-1 expression in a rat model of myocardial infarction, we cloned and functionally expressed the rat SDF-1alpha orthologue.
|
11820456 |
2001 |