CXCL12, C-X-C motif chemokine ligand 12, 6387

N. diseases: 626; N. variants: 21
Disease: Prostatic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group BEFREE These findings support the development of novel therapeutics targeting the CXCL12/CXCR4 axis as an ancillary to those targeting the androgen/AR axis to effectively treat castration resistant/recurrent prostate tumors. 22245379 2012
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group LHGDN CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone. 18337451 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group LHGDN CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12. 18563594 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 GeneticVariation group LHGDN CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility. 17785557 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group LHGDN Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells. 17034033 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group CTD_human CXCL12 G801A polymorphism is a risk factor for sporadic prostate cancer susceptibility. 17785557 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression group LHGDN CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. 16114056 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group LHGDN The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. 15844659 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group LHGDN CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. 15467730 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group LHGDN CXCR4 and CXCL12 (SDF-1) in prostate cancer: inhibitory effects of human single chain Fv antibodies. 15328206 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression group LHGDN Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. 12761880 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 AlteredExpression group LHGDN Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. 11912162 2002