|
Pancreatitis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Loss of subcutaneous adipose tissue in limbs
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Decreased serum leptin
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Calf muscle hypertrophy
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Marked muscular hypertrophy
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Loss of gluteal subcutaneous adipose tissue
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Decreased adiponectin level
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
An FSP27 knockout mouse demonstrated lean phenotypes with atrophic adipose tissue as a result of high-energy expenditure; this mouse line was also resistant to diet-induced obesity and insulin resistance.
|
20190390 |
2010 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
Here, we aimed to investigate lipid droplet protein (CIDEC/FSP27 and perilipinA (PLIN1)) gene expression in human adipose tissue in association with obesity, insulin resistance and mitochondrial gene expression.
|
24126816 |
2014 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
In both sc and visceral adipose tissue, FNDC5 gene expression decreased significantly in association with obesity and was positively associated with brown adipose tissue markers, lipogenic, insulin pathway-related, mitochondrial, and alternative macrophage gene markers and negatively associated with LEP, TNFα, and FSP27 (a known repressor of brown genes).
|
23436919 |
2013 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
Animals with deficiency in Cidea, Cideb, and Fsp27 all display lean phenotypes with higher energy expenditure and are resistant to diet-induced obesity and insulin resistance.
|
19276890 |
2009 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
Data show that ASO-Fsp27 and fenofibrate synergize to promote resistance to diet-induced obesity and hypertriglyceridemia and to reverse hepatic steatosis, inflammation, oxidative stress, and fibrosis.
|
28874443 |
2017 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
FSP27 and Links to Obesity and Diabetes Mellitus.
|
30919313 |
2019 |
|
Obesity
|
0.090 |
Biomarker
|
disease |
BEFREE |
Thus, the present study suggests that PCB-138-induced LD enlargement endows adipocytes with resistance to TNF-α-induced cell death and that Fsp27, perilipin, and survivin, at least in part, help adipocytes to sustain enlarged LDs, contributing to the induction of obesity.
|
29704545 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
This review discusses the physiological and metabolic actions of GH on adipose tissue as well as GH-mediated deregulation of the FSP27-PPARγ axis which alters adipose tissue homeostasis and contributes to the development of insulin resistance and Type 2 diabetes.
|
31599132 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry showed that more proliferating cell nuclear antigen-positive pulmonary arterial smooth muscle cells could be seen in type 2 diabetes rats; and after CIDEC gene silencing, proliferating cell nuclear antigen positive cells decreased accordingly.
|
29078040 |
2018 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
FSP27 and Links to Obesity and Diabetes Mellitus.
|
30919313 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The current status of the physiological roles of FSP27/CIDEC in adipose tissue and liver are discussed along with its significance as a factor involved in the development of metabolic disorders.
|
20190390 |
2010 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36).
|
28038473 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results suggest that <i>ARL14</i> has an important role in the pathogenesis of lung adenocarcinoma through CIDEC/ERK/p38 signaling pathway, and thus it could be applied as a new candidate of prognosis indicator and/or therapeutic target of lung adenocarcinoma.
|
31750299 |
2019 |
|
Asymmetric Septal Hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fsp27(Hep-/-) mice and mice given injections of adenovirus-Fsp27shRNA had markedly reduced ASH following chronic-plus-binge ethanol feeding.
|
26099526 |
2015 |
|
Metabolic Syndrome X
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that therapeutic silencing of Fsp27 with ASOs may be beneficial in the prevention and management of atherogenic disease in patients with metabolic syndrome.
|
29859472 |
2018 |
|
Alcoholic Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.
|
26099526 |
2015 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exercise decreased the levels of hepatic lipogenic markers carbohydrate‑responsive element‑binding protein, fat‑specific protein 27 and liver X receptor and improved systemic glucose and insulin intolerance in the NASH animal model.
|
31702809 |
2019 |