Malignant neoplasm of breast
|
0.340 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Claspin expression is significantly high in several human solid tumors.
|
22731782 |
2012 |
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLSPN small interfering RNA treatment decreased GC cell proliferation and invasion.
|
30240769 |
2019 |
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLSPN small interfering RNA treatment decreased GC cell proliferation and invasion.
|
30240769 |
2019 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
CLSPN small interfering RNA treatment decreased GC cell proliferation and invasion.
|
30240769 |
2019 |
Mammary Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
A separate analysis of the CLSPN c.3839C>T (rs35490896) variant that was observed more frequently in breast tumors than in pancreatic tumors or normal controls failed to detect a significant association with breast cancer risk in a Mayo Clinic breast cancer case-control study.
|
18281469 |
2008 |
Malignant neoplasm of breast
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
A separate analysis of the CLSPN c.3839C>T (rs35490896) variant that was observed more frequently in breast tumors than in pancreatic tumors or normal controls failed to detect a significant association with breast cancer risk in a Mayo Clinic breast cancer case-control study.
|
18281469 |
2008 |
Breast Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
A separate analysis of the CLSPN c.3839C>T (rs35490896) variant that was observed more frequently in breast tumors than in pancreatic tumors or normal controls failed to detect a significant association with breast cancer risk in a Mayo Clinic breast cancer case-control study.
|
18281469 |
2008 |
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Accumulating evidence suggests that Claspin inactivation could be an essential event during carcinogenesis, indicating that Claspin may function as a tumour suppressor.
|
28942358 |
2017 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Accumulating evidence suggests that Claspin inactivation could be an essential event during carcinogenesis, indicating that Claspin may function as a tumour suppressor.
|
28942358 |
2017 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among these dysregulated RNAs, three DELs (AP002478.1, HTR2A-AS1, and ERVMER61-1) and six DEGs (enhancer of zeste homolog 2 [<i>EZH2</i>], kinesin family member 23 [<i>KIF23</i>], chromobox 2 [<i>CBX2</i>], centrosomal protein 55 [<i>CEP55</i>], cell division cycle 25A [<i>CDC25A</i>], and claspin [<i>CLSPN</i>]) were used for construct a prognostic signature for HCC overall survival (OS), and performed well in HCC OS (adjusted <i>P</i><0.0001, adjusted hazard ratio = 2.761, 95% confidence interval = 1.838-4.147).
|
31289599 |
2019 |
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
As expected for a protein with key roles in checkpoint signalling and genome duplication, aberrations of Claspin expression and structure have been observed in cancer.
|
29931808 |
2019 |
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
As expected for a protein with key roles in checkpoint signalling and genome duplication, aberrations of Claspin expression and structure have been observed in cancer.
|
29931808 |
2019 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Being a key player in the replication stress response, checkpoint activation, and the DNA damage response, Claspin constitutes an attractive therapeutic target in cancer, namely for radio- and chemo-sensitization.
|
30798932 |
2019 |
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Being a key player in the replication stress response, checkpoint activation, and the DNA damage response, Claspin constitutes an attractive therapeutic target in cancer, namely for radio- and chemo-sensitization.
|
30798932 |
2019 |
Ataxia Telangiectasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both the ATR (ataxia telangiectasia and Rad3-related protein) kinase and the Replication pausing complex (RPC) components Tipin, Tim1 and Claspin play key roles in activating the intra S-phase checkpoint and in stabilizing the stalled replication forks.
|
22324461 |
2012 |
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of TopBP1 or Claspin using shRNA showed an enhancement of sensitivity to radiation in radioresistant lung cancer cells (PC14PE6).
|
25216549 |
2014 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of TopBP1 or Claspin using shRNA showed an enhancement of sensitivity to radiation in radioresistant lung cancer cells (PC14PE6).
|
25216549 |
2014 |
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of TopBP1 or Claspin using shRNA showed an enhancement of sensitivity to radiation in radioresistant lung cancer cells (PC14PE6).
|
25216549 |
2014 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Functional analyses indicated that the expression TopBP1 and Claspin positively affects the survival of cancer cells and thus negatively the xenograft metastasis model animals in response to radiation.
|
25216549 |
2014 |
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
Germline alterations in the CLSPN gene in breast cancer families.
|
18077083 |
2008 |
Carcinogenesis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Here, we describe a study to determine whether mutational disruption of CLSPN contributes to cancer susceptibility and sporadic tumorigenesis.
|
19737971 |
2009 |
Malignant Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
In addition, we identified three heterozygous candidate missense variants in known cancer susceptibility genes (BMPR1A, BRIP1, and SRC), three truncating variants in possibly novel cancer genes (CLSPN, SEC24B, SSH2) and four candidate missense variants in ACACA, NR2C2, INPP4A, and DIDO1.
|
30809968 |
2019 |
Primary malignant neoplasm
|
0.060 |
GeneticVariation
|
group |
BEFREE |
In addition, we identified three heterozygous candidate missense variants in known cancer susceptibility genes (BMPR1A, BRIP1, and SRC), three truncating variants in possibly novel cancer genes (CLSPN, SEC24B, SSH2) and four candidate missense variants in ACACA, NR2C2, INPP4A, and DIDO1.
|
30809968 |
2019 |
Human papilloma virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In order to investigate whether claspin immunoreactivity is related to the lesion severity and High-Risk (HR) HPV infection, we analyzed claspin expression by immunohistochemistry in a series of cervical biopsies which represent the steps occurring during cervical carcinogenesis (normal tissues, Cervical Intraepithelial Neoplasias 1, 2 and 3, Squamous Cell Carcinomas).
|
22731782 |
2012 |