|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and healthy human carriers.
|
2177094 |
1990 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Low sequence similarity in the putative envelope protein (greater than 53% identity), however, would have to be taken into account in considering the immunoprophylaxis of HCV infection.
|
1658196 |
1991 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of hypervariable regions in the putative envelope protein of hepatitis C virus.
|
1333186 |
1992 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
This finding suggests that nucleotide mutations in the envelope region of the viral genome may be responsible for the recurrent hepatic injury attributed to recurrence of viremia in patients with hepatitis C. From these aspects, the serial divergence of the virus genome in infected individuals, especially in the region encoding the viral envelope protein, may possibly play an important role in developing chronic infection of hepatitis C virus.
|
1330930 |
1992 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prevalence of antibody to the protein encoded by the NS1 region was lower than that of antibody to the HCV core protein, but much higher than that of antibody to the envelope protein.
|
1379627 |
1992 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.
|
1314389 |
1992 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recombinant baculoviruses that produce a putative non-structural protein 1 (NS1) of hepatitis C virus (HCV), predicted to be the second envelope glycoprotein, were constructed.
|
7686870 |
1993 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sequence variation in the large envelope glycoprotein (E2/NS1) of hepatitis C virus during chronic infection.
|
8382721 |
1993 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
These studies provide evidence that the highly conserved core protein is a target for HCV-specific CTL and identify CTL epitopes within the more highly variable E2 envelope protein.
|
7693974 |
1993 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinemic patient.
|
8143975 |
1994 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The hypervariable region 1 (HVR1) of the putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV) contains a sequence-specific immunological B-cell epitope that induces the production of antibodies restricted to the specific viral isolate, and anti-HVR1 antibodies are involved in the genetic drift of HVR1 driven by immunoselection (N. Kato, H. Sekiya, Y. Ootsuyama, T. Nakazawa, M. Hijikata, S. Ohkoshi, and K. Shimotohno, J. Virol.67:3923-3930, 1993).
|
7518526 |
1994 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hepatitis C virus (HCV) genome shows extensive sequence diversity at 2 hypervariable regions (HVR1 and HVR2) of the putative envelope glycoprotein (gp70).
|
8314302 |
1994 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
To identify conserved humoral antigenic determinants within the hepatitis C virus (HCV) envelope protein E2, we expressed a peptide library containing random short fragments of the HCV envelope in yeast.
|
7510436 |
1994 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the implications of sequence variability in HVRI of HCV, we investigated the sequence variability of the whole envelope-protein(gp35 and gp70)-coding regions of HCV genome derived from patient M in acute and relapsed phases (8-month interval) of hepatitis.
|
7515022 |
1994 |
|
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses.
|
8083956 |
1994 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
This confirms the presence of a hypervariable region (HVR1) in this envelope protein found in all hepatitis C viruses.
|
7832643 |
1994 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of the structural protein region revealed extremely low sequence homology with all the four major HCV genotypes: 86-89% for the core protein and 56-69% for the envelope protein.
|
7602082 |
1995 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variability of HCV was assessed by determining the nucleotide sequence corresponding to the hypervariable regions (HVR1 and HVR2) of the putative envelope protein (E2/NS1) in positive- and negative-stranded HCV RNA from the cancerous and surrounding non-cancerous liver tissue, peripheral blood mononuclear cells and serum of a patient with HCC.
|
8760588 |
1996 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that testing for anti-E2 may be useful for improving the performance of the current assays for anti-HCV screening and confirmation.
|
9123926 |
1996 |
|
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that the E2/NS1 antibody tested exhibits no neutralizing activity in chronic HCV infection but may serve as a serological indicator of active virus replication.
|
8621173 |
1996 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic heterogeneity of HCV is greatest in the amino-terminal end of the second envelope protein (hypervariable region 1).
|
9305657 |
1997 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
A second-generation immunoblot assay detected 98 percent of seropositive sera, a second-generation recombinant immunoblot assay detected 96 percent, and an enzyme immunoassay for antibody to the envelope protein of HCV detected 98 percent.
|
9051098 |
1997 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evolution of hepatitis G virus infection and antibody response to envelope protein in patients with transfusion-associated non-A, non-B hepatitis.
|
9658367 |
1998 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evolution of the hepatitis C virus second envelope protein hypervariable region in chronically infected patients receiving alpha interferon therapy.
|
10400744 |
1999 |
|
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum levels of HCV RNA and HGV RNA were detected by polymerase chain reaction (PCR) assays, and antibodies to HCV and HGV envelope protein E2 were detected by enzyme-linked immunosorbent assay.
|
10825044 |
1999 |