Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 Biomarker disease BEFREE 42% (15 of 21 specimens), but there was only 40% positivity (8 of 20 specimens) for hepatitis B virus envelope antigen whereas 6 of 17 patients (35.29%) showed the presence of antibodies against hepatitis B virus envelope protein. 10738214 2000
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 (HIV-1) entry is triggered by the interaction of the gp120 envelope glycoprotein with a cellular chemokine receptor, either CCR5 or CXCR4. 11356952 2001
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 GeneticVariation group BEFREE Herpes simplex virus (HSV) entry requires the interaction between the envelope glycoprotein D (gD) and a cellular receptor such as nectin-1 (also named herpesvirus entry mediator C [HveC]) or HveA/HVEM. 11836420 2002
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker disease BEFREE Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. 12615904 2003
CUI: C0019159
Disease: Hepatitis A
Hepatitis A
0.040 Biomarker disease BEFREE Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. 12615904 2003
Human immunodeficiency virus (HIV) II infection category B1
0.100 AlteredExpression disease BEFREE Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism. 16001969 2005
CUI: C0021400
Disease: Influenza
Influenza
0.100 Biomarker disease BEFREE Influenza M2 envelope protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors. 16397505 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker disease BEFREE Hepatitis C virus envelope glycoprotein co-evolutionary dynamics during chronic hepatitis C. 18343477 2008
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) is subject to both neutralizing antibody (NAb) and CD8 T-cell (cytotoxic T-lymphocyte [CTL]) immune pressure. 19515763 2009
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation disease BEFREE Human immunodeficiency virus 1 (HIV-1) encephalopathy is thought to result in part from the toxicity of HIV-1 envelope glycoprotein gp120 for neurons. 19525894 2009
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the interaction between a variably glycosylated envelope glycoprotein (gp120) and host-cell receptors. 20439465 2010
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Herpes simplex virus (HSV) entry into cells is triggered by the binding of envelope glycoprotein D (gD) to a specific receptor, such as nectin-1 or herpesvirus entry mediator (HVEM), resulting in activation of the fusion effectors gB and gH and virus penetration. 20861246 2010
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.100 Biomarker group BEFREE Herpes simplex virus entry into cells requires the binding of envelope glycoprotein D (gD) to an entry receptor. 21382632 2011
CUI: C1175175
Disease: Severe Acute Respiratory Syndrome
Severe Acute Respiratory Syndrome
0.020 Biomarker disease BEFREE Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis. 22028656 2011
CUI: C0021400
Disease: Influenza
Influenza
0.100 Biomarker disease BEFREE Influenza virus hemagglutinin (HA) is the viral envelope protein that mediates viral attachment to host cells and elicits membrane fusion. 22072785 2012
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker disease BEFREE Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host. 22855498 2012
CUI: C0021345
Disease: Infectious Mononucleosis
Infectious Mononucleosis
0.010 Biomarker disease BEFREE Infectious mononucleosis and B-cell transformation in response to infection with Epstein-Barr virus (EBV) is dependent upon binding of the EBV envelope glycoprotein gp350 to CD21 on B-cells. 23665339 2013
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.100 GeneticVariation disease BEFREE Dengue-1 envelope protein domain III produced in Pichia pastoris: potential use for serological diagnosis. 23993978 2013
CUI: C1096184
Disease: West Nile viral infection
West Nile viral infection
0.100 GeneticVariation disease BEFREE West Nile virus genome with glycosylated envelope protein and deletion of alpha helices 1, 2, and 4 in the capsid protein is noninfectious and efficiently secretes subviral particles. 24049184 2013
CUI: C0021400
Disease: Influenza
Influenza
0.100 Biomarker disease BEFREE Influenza vaccines must be frequently reformulated to account for antigenic changes in the viral envelope protein, hemagglutinin (HA). 26739054 2016
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker disease BEFREE Hepatitis C Virus Subtype 3a Envelope Protein 1 Binding with Human Leukocyte Antigen Class I Types of Pakistani Population: Candidate Epitopes for Synthetic Peptide Vaccine. 26742442 2015
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker disease BEFREE Hepatitis C virus (HCV) envelope glycoprotein complex is composed of E1 and E2 subunits. 28179528 2017
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Human immunodeficiency virus (HIV) envelope glycoprotein (glycoprotein 120, gp120) can induce chronic neuropathic pain by directly stimulating primary sensory afferent neurons. 28827078 2018
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type-1 (HIV-1) envelope glycoprotein 120 has been shown to activate microglia, causing release of inflammatory and toxic factors. 28832643 2017
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 (HIV-1) assembles as immature particles, which require the proteolytic cleavage of structural polyprotein Gag and the clustering of envelope glycoprotein Env for infectivity. 28916807 2017