Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker group BEFREE The first step of HIV infection involves the interaction of the gp120 envelope glycoprotein to its receptor CD4, mainly expressed on CD4+ T cells. 28346521 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker group BEFREE Thus, the gp41 HR1 region contributes to the association with gp120 and regulates Env transitions from the unliganded state to downstream conformations.<b>IMPORTANCE</b> The development of an efficient vaccine able to prevent HIV infection is a worldwide priority. 28003492 2017
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 GeneticVariation group BEFREE An important step in human immunodeficiency virus infection involves the interaction between the viral envelope glycoprotein gp120 and the human host cell surface receptor CD4. 22117536 2012
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker group BEFREE Direct signaling by envelope glycoprotein killed CD4-negative γδ T cells and reproduced a defect observed in all patients with HIV disease. 21926353 2011
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker group BEFREE Short interfering RNA knockdown of endogenous UNG2 in primary cells showed that UNG2 is required for R5 but not X4 HIV infection and that this requirement is bypassed when HIV enters the target cell via vesicular stomatitis virus envelope-glycoprotein-mediated endocytosis. 20371602 2010
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker group BEFREE Enfuvirtide (T-20) is the first entry inhibitor approved for treatment of HIV infection and acts by inhibiting conformational changes in the viral envelope protein gp41 that are necessary for fusion of the virus and host cell membranes. 16706613 2006
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker group BEFREE In addition, the alpha chemokine SDF1alpha and the beta chemokines MIP1alpha, MIP1beta, and RANTES, natural ligands of CXCR4 and CCR5, respectively, are potent soluble inhibitors of HIV infection by blocking the binding between the viral envelope glycoprotein gp120 and the coreceptors. 10820198 2000
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 AlteredExpression group BEFREE Susceptibility of cells to HIV infection is correlated with CD26 expression, and HIV transactivator Tat and envelope protein gp120 are reported to interact with CD26. 10698152 2000