|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
More specifically, we identified an epitope on Zika virus (ZIKV) envelope protein domain III (EDIII) that is buried in the full-length envelope protein but becomes exposed in recombinant EDIII.
|
31189716 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we established a competitive amplified luminescent proximity homogeneous assay (ALPHAscreen) to identify small molecule inhibitors targeting the envelope protein of Zika virus (Zika E).
|
30771406 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mechanistic study indicated that gossypol could neutralize ZIKV infection by targeting the envelope protein domain III (EDIII) of ZIKV.
|
31684080 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The envelope protein of Zika virus (ZIKV) exists as a dimer on the mature viral surface and is an attractive antiviral target because it mediates viral entry.
|
31138647 |
2019 |
|
Zika Virus Infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the present study demonstrates that the lateral ridge region of the envelope protein is likely an immunodominant, neutralizing epitope.<b>IMPORTANCE</b> Zika virus (ZIKV) is a global health threat causing severe disease in humans, including microcephaly in newborns and Guillain-Barré syndrome in adults.
|
31043537 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The population coverage was pan world and nearly 70% identity of the peptide was found in the Zika virus envelope protein.
|
31300121 |
2019 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cross-reactive dengue virus-derived monoclonal antibodies to Zika virus envelope protein: Panacea or Pandora's box?
|
30526531 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The interactions between the phytocompounds and Envelope protein (PDB id: 5JHM) of Zika virus was assessed with SYBYL-X 1.3.
|
30471642 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Optimization of Zika virus envelope protein production for ELISA and correlation of antibody titers with virus neutralization in Mexican patients from an arbovirus endemic region.
|
30587198 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Development of Envelope Protein Antigens To Serologically Differentiate Zika Virus Infection from Dengue Virus Infection.
|
29263206 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, TRPV4 mediates Ca<sup>2+</sup> influx and nuclear accumulation of DDX3X in cells exposed to the Zika virus or the purified viral envelope protein.
|
29899501 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant Zika virus envelope protein elicited protective immunity against Zika virus in immunocompetent mice.
|
29590178 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plant-produced Zika virus envelope protein elicits neutralizing immune responses that correlate with protective immunity against Zika virus in mice.
|
28710796 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, E90 could protect mice from ZIKV infection even at 140 days post-immunization.
|
30097059 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Zika virus envelope protein glycan loop regulates virion antigenicity.
|
29304471 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies have identified potential B-cell epitopes (amino acids 241-259, 294-315, 317-327, 346-361, 377-388 and 421-437) on the envelope protein of ZIKV, which could be explored to develop peptide vaccines against ZIKV infection.
|
29395533 |
2018 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epigallocatechin gallate, an active green tea compound inhibits the Zika virus entry into host cells via binding the envelope protein.
|
28666829 |
2017 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using 60 sequences of the Zika virus envelope protein available in the GenBank database, our analysis with numerical characterization techniques and several web based bioinformatics servers identified four peptide stretches on the Zika virus envelope protein that are well conserved and surface exposed and are predicted to have reasonable epitope binding efficiency.
|
28342423 |
2017 |
|
Zika Virus Infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also demonstrated that the Zika virus (ZIKV) VLP production level was enhanced by introducing the same F108A mutation into the ZIKV envelope protein.
|
28956764 |
2017 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunization with truncated envelope protein of Zika virus induces protective immune response in mice.
|
28855646 |
2017 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
As a proof of concept, we utilized our plasmonic metasurface to detect Zika-virus (ZIKV) envelope protein (with diameter of 40 nm) using a specific ZIKV antibody.
|
28792206 |
2017 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Study of the mechanism of protonated histidine-induced conformational changes in the Zika virus dimeric envelope protein using accelerated molecular dynamic simulations.
|
28445832 |
2017 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using 153 patient specimens with known ZIKV and/or dengue virus (DENV; a closely related flavivirus) infections, we showed that (i) ZIKV envelope-based MIA is equivalent or more sensitive than IgM-capture ELISA in diagnosing ZIKV infection, (ii) antibody responses to NS1 and NS5 proteins are more ZIKV-specific than antibody response to envelope protein, (iii) inclusion of NS1 and NS5 in the MIA improves the diagnostic accuracy when compared with the MIA that uses envelope protein alone.
|
28094237 |
2017 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Virus-like particles that display Zika virus envelope protein domain III induce potent neutralizing immune responses in mice.
|
28794424 |
2017 |
|
Zika Virus Infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus.
|
28669618 |
2017 |