Multiple Myeloma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Using mouse haplotype analysis, human MM SNP array data, and whole exome and whole genome sequencing of KaLwRij mice, we identified novel KaLwRij gene variants, including deletion of Samsn1 and deleterious point mutations in Tnfrsf22 and Tnfrsf23.
|
26020268 |
2015 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
SAMSN1 was expressed at significantly lower levels in tumor tissue compared with the corresponding noncancerous tissues of patients with HCC.
|
25805236 |
2015 |
Multiple Myeloma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Notably, re-expression of Samsn1 in the 5TGM1 murine PC line resulted in complete inhibition of MM disease development in vivo and decreased proliferation in stromal cell-PC co-cultures in vitro.
|
25117979 |
2014 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
SAMSN1 is a tumor suppressor gene in multiple myeloma.
|
25117979 |
2014 |
Osteoarthritis, Knee
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a H<sub>2</sub>S donor, might affect gonarthrosis in rats.
|
30521368 |
2019 |
Gonarthrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a H<sub>2</sub>S donor, might affect gonarthrosis in rats.
|
30521368 |
2019 |
Acute-On-Chronic Liver Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
NASH Is the Most Rapidly Growing Etiology for Acute-on-Chronic Liver Failure-Related Hospitalization and Disease Burden in the United States: A Population-Based Study.
|
30861321 |
2019 |
Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
All three were intergenic; the most significant interaction was in a regulatory region associated with SAMSN1, a gene previously associated with atherosclerosis and B cell activation.
|
28355232 |
2017 |
Atherosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
All three were intergenic; the most significant interaction was in a regulatory region associated with SAMSN1, a gene previously associated with atherosclerosis and B cell activation.
|
28355232 |
2017 |
Angioimmunoblastic Lymphadenopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
More importantly, we identified mutations in TNFRSF21 (1/9), CCND3 (1/9) and SAMSN1 (1/9), which are not yet seen or strongly implicated in the pathogenesis of AITL.
|
28148900 |
2017 |
Hepatitis
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The levels of SAMSN1 mRNA in noncancerous liver were not affected by background liver inflammation or fibrosis.
|
25805236 |
2015 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, multivariate analysis identified SAMSN1 as an independent prognostic factor of HCC progression.
|
25805236 |
2015 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
|
24278465 |
2013 |
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Survival analysis based on the TCGA GBM data matrix and TMA multi-grade glioma dataset found that SAMSN1 expression was closely related to the prognosis of GBM, either PFS or OS (P<0.05).
|
24278465 |
2013 |
Malignant Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Affymetrix and Arrystar gene microarray data in the setting of glioma was analyzed to preliminarily study the expression pattern of SAMSN1 in glioma tissues, and Hieratical clustering of gene microarray data was performed to filter out genes that have prognostic value in malignant glioma.
|
24278465 |
2013 |
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
|
24278465 |
2013 |
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.
|
18523997 |
2008 |
Malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found frequent downregulation of two coding genes, SAMSN1 and USP25, as well as of three miRNA genes, miR-99a, let-7c, and miR-125b-2, which reside in the commonly deleted region in human lung cancer.
|
18523997 |
2008 |
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found frequent downregulation of two coding genes, SAMSN1 and USP25, as well as of three miRNA genes, miR-99a, let-7c, and miR-125b-2, which reside in the commonly deleted region in human lung cancer.
|
18523997 |
2008 |
Primary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found frequent downregulation of two coding genes, SAMSN1 and USP25, as well as of three miRNA genes, miR-99a, let-7c, and miR-125b-2, which reside in the commonly deleted region in human lung cancer.
|
18523997 |
2008 |
Down Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Protein expression of HACS1 was significantly and remarkably decreased in DS, and the expression levels of five proteins were comparable between DS and controls suggesting that the gene dosage effect hypothesis is not sufficient to fully explain the DS phenotype.
|
12624743 |
2003 |
Complete Trisomy 21 Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Protein expression of HACS1 was significantly and remarkably decreased in DS, and the expression levels of five proteins were comparable between DS and controls suggesting that the gene dosage effect hypothesis is not sufficient to fully explain the DS phenotype.
|
12624743 |
2003 |
Hematopoietic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
HACS1 maps to human chromosome 21q11.2 in a region that is frequently disrupted by translocation events in hematopoietic malignancies.
|
11536050 |
2001 |