Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
65 genomic DNA samples from such patients were tested for the presence of three main Crohn associated mutations in CARD15 by direct genomic sequencing.
|
15990626 |
2005 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
: These results indicate that NOD2 genotype, smoking status, and TNFSF15 genotype should be included as covariates in assessing the effect of genetic and environmental factors on Crohn's disease site location.
|
21730793 |
2011 |
Crohn Disease
|
1.000 |
Biomarker
|
disease |
BEFREE |
Crohn's disease (CD) is a complex genetic disorder for which a susceptibility gene, IBD1, has been mapped within the pericentromeric region of chromosome 16.
|
11781683 |
2001 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
LHGDN |
Crohn's disease is caused by mutations in the bacterial response protein NOD2.
|
11837220 |
2001 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.
|
12512038 |
2003 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease is the result of an abnormal immune response of the gut mucosa triggered by one or more environmental risk factors in people with predisposing gene variations, including CARD15 mutations.
|
14683664 |
2003 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease-associated polymorphisms of NOD2 show a decreased ability to bind RIP2, and this decreased ability to bind RIP2 correlates with a decreased ability to ubiquitinylate NEMO.
|
15620648 |
2004 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes.
|
16198136 |
2005 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease incidence evolution in North-western Greece is not associated with alteration of NOD2/CARD15 variants.
|
17876878 |
2007 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease shows strong association with CARD15, ATG15L1, and IRGM, which are involved in the innate immunity.
|
19647622 |
2009 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1.
|
20144769 |
2010 |
Crohn Disease
|
1.000 |
AlteredExpression
|
disease |
BEFREE |
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2.
|
21406388 |
2011 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease-associated NOD 2 variants (Arg702Trp and 3020insC) were found to be monomorphic (wild), and 7 subjects were heterozygous for Gly908Arg SNP in 263 patients with tuberculosis, 260 patients with leprosy and 270 healthy controls residing in northern Indian states.
|
22289211 |
2012 |
Crohn Disease
|
1.000 |
Biomarker
|
disease |
BEFREE |
Crohn's disease is also caused by mutations in the gene encoding NOD2 but the mechanisms behind Crohn's disease development in XIAP and NOD2 deficient-patients are still unknown.
|
29743550 |
2018 |
Crohn Disease
|
1.000 |
Biomarker
|
disease |
BEFREE |
CARD15 has been involved in Crohn's Disease (CD) susceptibility and it has been hypothesised that it may also contribute to the pathogenesis of psoriasis.
|
12459523 |
2003 |
Crohn Disease
|
1.000 |
Biomarker
|
disease |
BEFREE |
CARD15 is a major susceptibility gene for a frequent multifactorial chronic inflammatory bowel disorder, Crohn disease (CD).
|
12626759 |
2003 |
Crohn Disease
|
1.000 |
Biomarker
|
disease |
BEFREE |
Nucleotide-binding oligomerization domain 2 (NOD2) belongs to an apoptotic regulatory family of genes and has been linked to CD.
|
12710125 |
2003 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
NOD 2, a defect present in approximately 50% of Crohn's disease patients, bears no relationship to non-response.
|
14550876 |
2003 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
NOD2 mutations are also associated with Crohn disease.
|
14597055 |
2003 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
CARD15 mutation frequencies were greater in affected sib pairs than in sporadic CD cases but actually decreased in families with three or more affected sibs, raising the possibility of genetic heterogeneity.
|
15024686 |
2004 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
UNIPROT |
CARD15 mutation frequencies were greater in affected sib pairs than in sporadic CD cases but actually decreased in families with three or more affected sibs, raising the possibility of genetic heterogeneity.
|
15024686 |
2004 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
NOD2 gene 3020insC frameshift mutation is not a major contributor to the susceptibility to both Crohn's disease and ulcerative colitis in Chinese Han patients.
|
15052696 |
2004 |
Crohn Disease
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
NOD2/caspase recruitment domain (CARD)15 variants are identified in up to 50% of Crohn's disease (CD) patients.
|
15190267 |
2004 |
Crohn Disease
|
1.000 |
Biomarker
|
disease |
BEFREE |
IBD1 and IBD3 determine location of Crohn's disease in the Spanish population.
|
15626888 |
2004 |
Crohn Disease
|
1.000 |
Biomarker
|
disease |
MGD |
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.
|
15692052 |
2005 |