Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Genetic polymorphisms present in IL10, IL23R, NOD2, and ATG16L1 associated with susceptibility to inflammatory bowel disease in Mexican population.
|
31651650 |
2020 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This review shows an overview of the genetic and environmental factors that appear to influence both the occurrence of IBD and CRC with particular reference to <i>NOD2</i> and <i>TLRs</i> as well as pro- and anti-inflammatory cytokines associated with tumor initiation and progression (encompassing both tumor invasion and metastases), as they constitute potential targets for therapeutic intervention.
|
31338130 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Many variants overlapped with known IBD-associated genes (e.g.NOD2).
|
29593342 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome ("dysbiosis") in a patient cohort.
|
30818349 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
We evaluated the impact of variations in ATG16L1 and NOD2 and genes on serologic responses in patients with inflammatory bowel disease (IBD).
|
30265311 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
(2) We genotyped 163 known IBD risk loci and sequenced NOD2 in 22 patients with FGDS.
|
30353760 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Although the risk loci for IBD typically overlap between Asians and Westerners, genetic heterogeneity has been detected in many loci/genes, such as NOD2/CARD15, TNFSF15 and human leukocyte antigen, contributing to the risk of IBD.
|
31052430 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The importance of these proteins is also highlighted by the genetic association between single nucleotide polymorphisms in NOD2 and susceptibility to Crohn's disease, an inflammatory bowel disease.
|
30578751 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Subsequently, KEGG generated bacterial TLR4 and NOD2 transcriptional signatures strongly associated with inflamed IBD transcriptomes and with the Mito-0 signature as determined by Spearman's analysis (coefficient of correlation, r = 0.92, p < .05).
|
31063017 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
AlteredExpression
|
group |
BEFREE |
These studies thus suggest that NOD1- or NOD2-independenent activation of RICK plays a major role in both murine experimental colitis and human IBD.
|
31132297 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
NOD2 mutations increase the susceptibility to inflammatory bowel diseases and the CD1d bound to α-galactosylceramide [α-GalCer] alleviates intestinal inflammation.
|
31094420 |
2019 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease.
|
30008619 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These results open a new scenario for therapeutic attempt to re-establish eubiosis in Inflammatory Bowel Disease patients with NOD2 polymorphisms.
|
30250234 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Screening of Cytotoxicity and Anti-Inflammatory Properties of Feijoa Extracts Using Genetically Modified Cell Models Targeting TLR2, TLR4 and NOD2 Pathways, and the Implication for Inflammatory Bowel Disease.
|
30200338 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
All variants identified are known in literature as being associated with IBD except for three variants in the genes NOD2, IL10 and IL10RB that even though present in online databases have never been involved in association studies on IBD patients.
|
29248579 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
We described the case of a baby with a very early-onset IBD who is characterized by a rare homozygous variant in NOD2, found through whole-exome sequencing, Its pathogenic effect was investigated through bioinformatics and functional studies.
|
29697845 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
A better understanding of how host genetics, including NOD2, influence immune-microbe interactions and alter susceptibility to IBD is necessary in order to develop therapeutic and preventative treatments.
|
29806140 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The main objective of this study was to analyze the correlation between the CTLA-4 gene +49A/G polymorphism and the NOD2/CARD15 gene N852S polymorphism in Turkish patients with IBD using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis.
|
30213296 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Common gene polymorphisms linked with IBD (NOD2, ATG16L1, IRGM and IL23R) were not associated with bacterial translocation.
|
29893034 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is a cytosolic innate immune receptor associated with inflammatory bowel disease susceptibility.
|
30012848 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
NOD-2 and A20 have specifically been found to be strongly associated with pediatric IBD.
|
30425977 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
HLA-B27 but not NOD-2 was a predisposing factor for the inflammatory back disorders in IBD patients.
|
28961700 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Mutations in NOD2 predisposes to Inflammatory Bowel Diseases.
|
30041769 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
GeneticVariation
|
group |
BEFREE |
To investigate the frequency of NOD2/CARD15 mutations in IBD Bedouin patients and their relevance to disease phenotype.
|
30430799 |
2018 |
Inflammatory Bowel Diseases
|
0.500 |
Biomarker
|
group |
BEFREE |
Genetics of inflammatory bowel disease: beyond NOD2.
|
28404137 |
2017 |