|
Multiple disability
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to analyse a possible association of three autoimmune disabilities - Multiple sclerosis (MS), LADA diabetes and Graves' disease (GD) with single nucleotide polymorphism (SNP; rs1990760) in the IF IH1 gene (also known as a melanoma differentiation-associated protein 5 - MDA5) within the Polish population.
|
31733941 |
2020 |
|
Trichohepatoenteric Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The syndrome is genetically heterogeneous with mutations in 7 genes, including <i>TREX1</i>, <i>RNASEH2A</i>, <i>RNASEH2B</i>, <i>RNASEH2C</i>, <i>SAMHD1</i>, <i>ADAR1</i>, and <i>IFIH1</i> (interferon-induced helicase c domain-containing protein 1) associated with the syndrome, so far.
|
30952201 |
2020 |
|
Connective Tissue Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
For distinguishing DM/PM from other CTDs, the sensitivity, specificity, and positive predictive value (PPV) for anti-MDA5 were 28.46, 99.00, and 97.37%, respectively, with a positive likelihood ratio (LR+) of 28.46; they were 46.15, 58.00, and 58.82%, respectively, for anti-Ro-52 with an LR+ of 1.10.
|
30616054 |
2019 |
|
Japanese Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5.
|
30481615 |
2019 |
|
Heart valve disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In children, non-neurological involvement in the type I interferonopathies includes autoimmune and rheumatological phenomena, with calcifying cardiac valve disease only previously reported in the context of MDA5 gain-of-function.
|
31772029 |
2019 |
|
Skin Manifestations
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Anti-MDA5 antibody may be associated with CADM, the progression to RP-ILD, high serum ferritin level, and characteristic skin manifestations.
|
31617496 |
2019 |
|
West Nile Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
While LGP2 functions to modulate inflammatory signaling, RIG-I and MDA5 together are essential for M1 macrophage polarization in vivo and the control of WNV infection through potential downstream control of ATF4 and SMAD4 to regulate target gene expression for cell polarization.
|
31409781 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
The expressions of B-cell lymphoma-associated X-2 (Bax-2), B-cell lymphoma-2 (Bcl-2), phosphoinositide-3-kinase (PI3K), protein kinase B (Akt), glycogen synthase kinase 3β (GSK-3β), MDA5 and SOD1 were determined using western blotting assay.
|
30858867 |
2019 |
|
T-Lymphocytopenia, Idiopathic CD4-Positive
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hypomyopathic Dermatomyositis Presenting with Idiopathic CD4 T-lymphocytopenia and Delayed Anti-MDA5 Positivity.
|
31058016 |
2019 |
|
Duck viral enteritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, the transcriptional level of MDA5 was upregulated both in vivo and in vitro upon DEV infection.
|
31675523 |
2019 |
|
Hepatitis C, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations at IFIH1 rs3747517 and DDX58 rs9695310 were independent predictors of chronic hepatitis C in Chinese Han population.
|
30633820 |
2019 |
|
Pseudohyperkalemia Cardiff
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
IFIH1 rs3747517 (dominant model: Adjusted odds ratio [OR] = 1.34, 95% confidence interval [CI] = 1.07-1.68; P = 0.009) and DDX58 rs9695310 (dominant model: Adjusted OR = 1.43, 95% CI = 1.15-1.78; P = 0.001) were associated with chronic hepatitis C (CHC).
|
30633820 |
2019 |
|
Sex Differentiation Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that several 14-3-3 isoforms may interact with MDA5 through the CARDs (N-MDA5), but 14-3-3η was the only isoform that could enhance MDA5-dependent IFNβ promoter activities in a dose-dependent manner.
|
30742689 |
2019 |
|
Autoinflammatory disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recent work showed that mutations in the IFIH1 gene, encoding MDA5, lead to interferon-driven autoinflammatory diseases.
|
30201512 |
2019 |
|
Middle East Respiratory Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Middle East Respiratory Syndrome Coronavirus-Encoded Accessory Proteins Impair MDA5-and TBK1-Mediated Activation of NF-κB.
|
31434175 |
2019 |
|
Abnormality of the skeletal system
|
0.010 |
Biomarker
|
disease |
BEFREE |
Singleton-Merten Syndrome-like Skeletal Abnormalities in Mice with Constitutively Activated MDA5.
|
31366715 |
2019 |
|
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Initial aggressive immunosuppressive therapy should be considered for these patients.Key Points• This study clearly demonstrate the presence of PNM was associated with elevated risk of death due to respiratory failure from RP-ILD among patients with DM having circulating anti-MDA5-antibody.•This study demonstrate evaluation of CT image may be helpful to find patients with better response to the intense immunosuppression therapy for the patients with DM having circulating anti-MDA5-antibody and PNM.
|
31420814 |
2019 |
|
Tumour inflammation
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the absence of ADAR1, A-to-I editing of interferon-inducible RNA species is reduced, leading to double-stranded RNA ligand sensing by PKR and MDA5; this results in growth inhibition and tumour inflammation, respectively.
|
30559380 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Purpose:</b> Polyinosinic-polycytidylic acid-poly-l-lysine carboxymethylcellulose (poly-ICLC), a synthetic double-stranded RNA complex, is a ligand for toll-like receptor-3 and MDA-5 that can activate immune cells, such as dendritic cells, and trigger natural killer cells to kill tumor cells.<b>Patients and Methods:</b> In this pilot study, eligible patients included those with recurrent metastatic disease in whom prior systemic therapy (head and neck squamous cell cancer and melanoma) failed.
|
29950349 |
2018 |
|
Cholelithiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We describe associations that may predict ADEs, e.g., acne, high cholesterol, gout, and gallstones with rs738409 (rs738409" genes_norm="80339">p.I148M) in PNPLA3 and asthma with rs1990760 (p.T946A) in IFIH1.
|
30327483 |
2018 |
|
Colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Intriguingly, concurrent deletion of MDA5 restores thymocyte maturation and prevents colitis.
|
30361393 |
2018 |
|
Hepatitis D Infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
MDA5 is the key sensor for the recognition of hepatitis D virus replicative intermediates.
|
29524530 |
2018 |
|
Dyspnea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The MSN group experienced lower dyspnea (48.2% versus 79% versus 71.4%, P = 0.001) and fever (18.1% versus 39.5% versus 37.5%, P = 0.01) frequencies compared to MDA5 and ARS groups.
|
29289262 |
2018 |
|
Exanthema
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In exact logistic regressions adjusted for age, race/ethnicity, sex, amyopathic status, anti-Ro52 status, and dermatomyositis-associated cancer, the presence of anti-SAE-1/2 autoantibodies was significantly associated with a hydroxychloroquine-associated skin eruption (odds ratio [OR], 8.43; 95% CI, 1.98-49.19; P = .003) and presence of anti-MDA-5 autoantibodies was significantly negatively associated with a hydroxychloroquine-associated skin eruption (OR, 0.06; 95% CI, 0.0004-0.52; P = .006).
|
30140893 |
2018 |
|
Malaria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The difference in MDA5 expression between responding and non-responding NK cells following exposure to iRBCs likely contributes to the variation in NK cell responses to malaria infection in the human population.
|
30286211 |
2018 |