|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The IFIH1 rs1990760 polymorphism was genotyped in 1055 patients of Central-Eastern European ancestry with T1DM (median age at diagnosis: 8.2 [interquartile range, IQR 4.8-11.8] years).
|
28929635 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Importantly, this MDA5-dependent antiviral response is specific to the pancreas of rotavirus-infected mice, similar to the autoimmunity associated with T1D.
|
28851763 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In summary, our study uncovers an influence of rs1990760 on the canonical effector function of MDA5 in response to an acute infection of primary human parenchymal cells with a clinically relevant virus linked to human T1D.
|
28000722 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
These studies have provided a functional hypothesis for IFIH1 T1D-associated SNPs' effects on MDA5-mediated interferon responses as well as supporting the genome-wide association (GWA) studies that first associated IFIH1 with T1D.
|
26385483 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of PTPN22, CTLA4, and IFIH1 variants with T1D were investigated in a sample of 197 nuclear families, including 205 affected children, in the Colombian population.
|
25042601 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that although STAT4 and IFIH1 SNPs are not associated with T1D in a Brazilian population, they might play a role in susceptibility to T1D on a larger worldwide scale.
|
26782418 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
|
26485223 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether polymorphisms in the IFIH1 locus are a risk factor for T1D in Caucasian patients from Poland.
|
25515714 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Functional characterization of the Thr946Ala SNP at the type 1 diabetes IFIH1 locus.
|
24117221 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
DNA variation in IFN-inducible genes altered T1D risk (P = 0.007), as exemplified by IFIH1, one of the genes in our IFN signature for which increased expression is a known risk factor for disease.
|
24561305 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Using a relative gene expression method, we observed a lower expression of interferon-induced helicase 1 (IFIH1) and other type I IFN-induced genes in the blood cells of T1D subjects, especially subjects under 10 years old, in spite of their higher IFN levels as measured by the pSTAT1-inducing capacity of their sera.
|
24965593 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, a clear association has not been yet established between T1D-associated IFIH1 polymorphisms and enterovirus detection.
|
23549392 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The rs6432714, a tag-SNP that represents part of helicase domain of IF1H1 protein showed a trend of association only with T1D development (P>0.025 after Bonferroni adjustment) in log-additive model (OR=1.45, P=0.0365, power=0.99), indicating that helicase domain of IFIH1 protein could be associated with the susceptibility to T1D.
|
23246693 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Here, we investigated whether this polymorphism is associated with T1DM or its clinical characteristics in a Brazilian population, and if IFIH1 gene expression in mononuclear cells from T1DM patients differs according to the genotypes of this polymorphism.
|
24386202 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associated with type 1 diabetes.
|
22789000 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Autoantibodies to insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured in follow-up sera, and genotyping for type 1 diabetes susceptibility genes (HLA-DR/HLA-DQ, INS variable number of tandem repeats [VNTR] and single nucleotide polymorphisms at PTPN22, PTPN2, ERBB3, IL2, SH2B3, CTLA4, IFIH1, KIAA0350 [also known as CLEC16A], CD25, IL18RAP, IL10, COBL) was performed on the DNA samples of children born to a parent with type 1 diabetes and prospectively followed from birth for up to 22 years.
|
23539116 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Within this context, the objective of the present review was to address the role of IFIH1 in the development of T1DM.
|
24402011 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrates that the IFIH1 rs1990760 T-allele confers susceptibility to T1D, SLE, MS and RA and suggests that the IFIH1 rs1990760 polymorphism might have no effect on GD and AAD.
|
23734776 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The encoded protein (interferon-induced helicase C domain-containing protein 1) senses double-stranded RNA during replication of Picornavirales, including Enterovirus, a genus suspected in the etiology of type 1 diabetes.
|
23144876 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
USP18 depletion increases the expression of the T1D candidate gene MDA5, leading to an upregulation of double-stranded RNA-induced chemokine production.
|
23152055 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IFIH1 rs3747517, but not rs1990760 polymorphism, plays an important role in type 1 diabetes risk in Chinese Han population.
|
22053898 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Children of parents with type 1 diabetes and prospectively followed from birth for the development of islet autoantibodies and diabetes were genotyped for single-nucleotide polymorphisms at 12 type 1 diabetes susceptibility genes (ERBB3, PTPN2, IFIH1, PTPN22, KIAA0350, CD25, CTLA4, SH2B3, IL2, IL18RAP, IL10 and COBL).
|
22932816 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, cesarean section appeared to interact with immune response genes, including CD25 and in particular the interferon-induced helicase 1 gene, where increased risk for type 1 diabetes was only seen in children who were delivered by cesarean section and had type 1 diabetes-susceptible IFIH1 genotypes (12-year risk, 9.1 vs. <3% for all other combinations; P < 0.0001).
|
22110093 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
We further applied the odds ratio weighted method to the IFIH1 gene for type-1 diabetes in the WTCCC data.
|
21594893 |
2011 |