|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We evaluated Mkk4 protein expression patterns by immunohistochemical labeling in a series of 60 resected primary infiltrating pancreatic adenocarcinomas (24 cases with known MKK4 genetic status), and 14 different tissue arrays representing the primary carcinoma and all of the gross metastases from 26 patients that died of metastatic pancreatic cancer.
|
15623633 |
2004 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By contrast, MAP2K4 was downregulated in CAC.
|
28454307 |
2017 |
|
Adenocarcinoma of large intestine
|
0.500 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Adenocarcinoma of large intestine
|
0.500 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Adenocarcinoma of large intestine
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing PPARγ2 levels.
|
21896780 |
2011 |
|
Adenocarcinoma, Endometrioid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High-grade endometrioid adenocarcinoma (G2 and G3) (p = 0.024), postmenopausal status (p = 0.018), and patient age (≥ 60) (p = 0.012) were significantly correlated with lower MKK4 expression.
|
21372598 |
2010 |
|
Adenoma of large intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we used immunohistochemistry to assess phosphorylated MMK4 (pMKK4) levels and examine their association with the clinicopathological features of a pilot set of patient samples consisting of normal colonic mucosa (NCM), colorectal adenoma (CA), and colorectal cancer (CRC) tissues. pMKK4 levels were also assessed in a validation set of CRC cases with accompanying follow-up data to confirm their clinicopathological and prognostic significance. pMKK4 levels, which were high in 79.17% of NCM samples, were downregulated in 33.33% of CA and 63.54% of CRC samples. pMKK4 downregulation was associated with metastasis, especially to the liver.
|
28423721 |
2017 |
|
Adult Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings on rhabdomyosarcoma samples showed multiple copy number alterations in chromosome regions implicated in malignancy progression and indicated a strong expression of MAP2K4 and MCL1 genes, both involved in different biological functions of complicated signalling pathways.
|
19012245 |
2009 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Future studies will be needed to assess the specificity of MAPKAPK5 and MAP2K4 to eventual conversion to AD.
|
26080319 |
2015 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, high MKK4 expression and its combination with high MKK7 expression both predicted favorable prognosis in resectable PDAC.
|
30537492 |
2019 |
|
Atrial Fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, human atrial tissues in AF showed a Mkk4 downregulation associated with increased production of profibrotic molecules, compared to findings in tissue from control subjects in sinus rhythm.
|
24721794 |
2014 |
|
Benign tumor of pancreas
|
0.300 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Benign tumor of pancreas
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Brain Death
|
0.200 |
Biomarker
|
phenotype |
RGD |
Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death.
|
23157661 |
2012 |
|
Breast adenocarcinoma
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast adenocarcinoma
|
0.300 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In our study, MAP2K4 and Vimentin co-expression is confirmed to be an unfavorable factor in breast cancer.
|
31761784 |
2019 |
|
Breast Carcinoma
|
0.360 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In this study, we found an inverse association between MKK4 promoter polymorphism and breast cancer risk.
|
27509166 |
2016 |
|
Breast Carcinoma
|
0.360 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.
|
9622070 |
1998 |
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
The Metastasis Suppressor Genes (MSG) Nm23, KISS1, KAI1, BRMS1, and Mkk4 have been associated with the metastatic potential of breast cancer in vitro and in vivo.
|
15592684 |
2005 |
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
To determine the role of the MEKK1/SEK1/JNK1/AP-1 pathway in the action of Xihuang pill (XHP) in reducing regulatory T (Treg) cell numbers in the tumor microenvironment in a 4T1 mouse breast cancer model, and to clarify the anti-tumor mechanism of XHP in breast cancer.
|
29710529 |
2018 |
|
Breast Carcinoma
|
0.360 |
Biomarker
|
disease |
BEFREE |
To address this question, we studied an independent panel of 20 breast cancer cell lines and xenografts for MAP2K4 alterations.
|
11754110 |
2002 |